Evidence for a Causal Relationship Between Academic Achievement and Cigarette Smoking

Author:

Kendler Kenneth S12ORCID,Ohlsson Henrik3,Fagan Abigail A4,Lichtenstein Paul5,Sundquist Jan367ORCID,Sundquist Kristina367ORCID

Affiliation:

1. Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA

2. Department of Psychiatry, Virginia Commonwealth University, Richmond VA

3. Center for Primary Health Care Research, Lund University, Malmö, Sweden

4. Department of Sociology, Criminology & Law, University of Florida, Gainesville, FL

5. Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden

6. Department of Family Medicine and Community Health, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY

7. Center for Community-based Healthcare Research and Education (CoHRE), Department of Functional Pathology, School of Medicine, Shimane University, Matsue, Japan

Abstract

Abstract Introduction Academic achievement (AA) is associated with smoking rates. Can we determine the degree to which this relationship is likely a causal one? Methods We predict smoking in male conscripts (mean age 18.2) assessed from 1984 to 1991 (N = 233 248) and pregnant females (mean age 27.7) receiving prenatal care 1972–1990 (N = 494 995) from AA assessed in all students at 16. Instrumental variable (IV) analyses used the instrument month-of-birth as in each school year, older children have high AA. Co-relative analyses used AA-smoking associations in the population, cousins and siblings to predict the AA-smoking relationship in MZ twins, thereby controlling for familial confounding. Results In males, higher AA was associated with a substantial decrease in risk for smoking (odds ratio [OR] [95% confidence intervals [CIs]] per standard deviation [SD] = 0.41 [0.40–0.41]) while the parallel figures obtain from our IV and co-relative analyses were 0.47 (0.39–0.57) and 0.51 (0.43–0.60), respectively. In females, these figures for pre-pregnancy smoking were, respectively, 0.39 (0.39–0.39), 0.50 (0.46–0.54) and 0.54 (0.51–0.58). Results for heavy versus light smoking suggested a causal effect but were inconsistent across methods. However, among females smoking prior to pregnancy, AA predicted a reduced risk for continued smoking with ORs for uncontrolled, IV, and co-relative analyses equaling, respectively, were 0.54 (0.53–0.55) 0.68 (0.56–0.82) and 0.78 (0.66–0.91), respectively. Conclusions Two different methods produced consistent evidence that higher AA has a causal effect on reducing smoking rates and increasing cessation rates in smoking pregnant females. Improving AA may result in meaningful gains in population health through reduced smoking. Implications This study provides consistent evidence across two different methods that high AA is causally related to reduced rates of smoking and increasing rates of smoking cessation among pregnant women. Our results suggest that interventions that improve educational achievement in adolescence would reduce tobacco consumption, thereby improving public health.

Funder

National Institutes of Health

Swedish Research Council

Region Skåne

Avtal om Läkarutbildning och Forskning

Publisher

Oxford University Press (OUP)

Subject

Public Health, Environmental and Occupational Health

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