Common Liabilities in Internalizing Symptoms and Cigarette Use in Adolescence

Author:

Bares Cristina B1ORCID,Silberg Judy23,Kendler Kenneth S24ORCID,Maes Hermine H243

Affiliation:

1. University of Michigan, Ann Arbor, MI

2. Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA

3. Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA

4. Department of Psychiatry, Virginia Commonwealth University, Richmond, VA

Abstract

Abstract Introduction Substance use and mood disorders account for about 10% of the global burden of disease and, among adolescents, are a significant source of disability. The present study examined whether additive genetic or shared environmental factors influenced the covariance of internalizing symptoms and cigarette use during adolescence when both of these problems begin to increase. Aims and Methods We used data (n = 1230 pairs of twins) from the Virginia Twin Study of Adolescent Behavioral Development (mean age = 15.3) to decompose the variance of internalizing symptoms, cigarette initiation, and quantity of cigarettes smoked in a variance decomposition model that included a beta coefficient to allow for estimates of cigarette initiation to influence quantity of cigarettes smoked. Results In biometric models we were able to equate all parameter estimates by sex. After identifying the best fitting model, parameter estimates were calculated and the significance of overlapping paths between internalizing symptoms and cigarette initiation were tested. After accounting for the genetic architecture of cigarette initiation and quantity smoked, the covariance between internalizing symptoms and cigarette use was accounted for by sex-specific shared and unique environmental factors. Conclusions Among adolescents, the overlap in risk factors between internalizing symptoms and cigarette use is because of non-genetic, environmental factors. Further exploration of the environmental sources of variance involved in the onset of adolescents internalizing symptoms and cigarette use is warranted. Implications We find that during adolescence common environmental factors influence the association between internalizing symptoms and cigarette use. Correlated vulnerabilities because of environmental sources between internalizing and cigarette use may be open to intervention and likely will influence the progression of internalizing and cigarette use.

Funder

National Institute on Drug Abuse

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Public Health, Environmental and Occupational Health

Reference39 articles.

1. Grand challenges in global mental health;Collins;Nature,2011

2. A heavy burden on young minds: the global burden of mental and substance use disorders in children and youth;Erskine;Psychol Med,2015

3. Age of onset of mental disorders and use of mental health services: needs, opportunities and obstacles;de Girolamo;Epidemiol Psychiatr Sci,2012

4. Is there an epidemic of child or adolescent depression?;Jane Costello;J Child Psychol Psychiatry,2006

5. Disorders of childhood and adolescence: gender and psychopathology;Zahn-Waxler;Annu Rev Clin Psychol,2008

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