Chronic chikungunya disease (CCD): clinical insights, immunopathogenesis and therapeutic perspectives

Author:

Ng W H123,Amaral K4,Javelle E5678ORCID,Mahalingam S123ORCID

Affiliation:

1. Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University , Gold Coast, QLD, Australia

2. Global Virus Network (GVN) Centre of Excellence in Arboviruses, Griffith University , Gold Coast, QLD, Australia

3. School of Pharmacy and Medical Sciences, Griffith University , Gold Coast, QLD, Australia

4. Department of Health Sciences, Federal University of Cariri , Barbalha, Ceará, Brazil

5. Unité Parasitologie et Entomologie, Département Microbiologie et Maladies Infectieuses, Institut de Recherche Biomédicale des Armées , Marseille, France

6. Aix Marseille Université, IRD, SSA, AP-HM, VITROME , Marseille, France

7. Unit of Infectious Diseases and Tropical Medicine, IHU Méditerranée Infection , Marseille, France

8. Service de Pathologie Infectieuse et Tropicale, Hôpital d'Instruction des Armées Laveran , Marseille, France

Abstract

Abstract Chikungunya virus, an arthropod-borne pathogen is recognized by the World Health Organization as a top priority Emerging Infectious Disease and is ranked fourth in public health needs according to the Coalition for Epidemic Preparedness Innovations. Despite its substantial impact, as evidenced by an annual estimate of 120 274 disability-adjusted life years, our understanding of the chronic aspects of chikungunya disease remains limited. This review focuses on chronic chikungunya disease, emphasizing its clinical manifestations, immunopathogenesis, therapeutic options and disease burden.

Publisher

Oxford University Press (OUP)

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