Vaccination saves lives: a real-time study of patients with chronic diseases and severe COVID-19 infection
Author:
Mukherjee A1, Kumar G1, Turuk A1, Bhalla A2, Bingi T C3, Bhardwaj P4, Baruah T D5, Mukherjee S6, Talukdar A7, Ray Y8, John M9, Khambholja J R10, Patel A H11, Bhuniya S12, Joshi R13, Menon G R14, Sahu D14, Rao V V14, Bhargava B1, Panda S1, Mishra P, Panchal Y, Sharma L K, Agarwal A, Puri G D, Suri V, Singla K, Mesipogu R, Aedula V S, Mohiuddin M A, Kumar D, Saurabh S, Misra S, Kannauje P K, Kumar A, Shukla A, Pal A, Chakraborty S, Dutta M, Mondal T, Chakravorty S, Bhattacharjee B, Paul S R, Majumder D, Chatterjee S, Abraham A, Varghese D, Thomas M, Shah N, Patel M, Madan S, Desai A, Kala Yadhav M L, Madhumathi R, Chetna G S, Ojha U K, Jha R R, Kumar A, Pathak A, Sharma A, Purohit M, Sarangi L, Rath M, Shah A D, Kumar L, Patel P, Dulhani N, Dube S, Shrivastava J, Mittal A, Patnaik L, Sahoo J P, Sharma S, Katyal V K, Katyal A, Yadav N, Upadhyay R, Srivastava S, Srivastava A, Suthar N N, Shah N M, Rajvansh K, Purohit H, Mohapatra P R, Panigrahi M K, Saigal S, Khurana A, Panchal M, Anderpa M, Patel D, Salgar V, Algur S, Choudhury R, Rao M, Nithya D, Gupta B K, Kumar B, Gupta J, Bhandari S, Agrawal A, Shameem M, Fatima N, Pala S, Nongpiur V, Chatterji S, Mukherjee S, Shivnitwar S K, Tripathy S, Lokhande P, Dandu H, Gupta A, Kumar V, Sharma N, Vohra R, Paliwal A, Pavan Kumar M, Bikshapathi Rao A, Kikon N, Kikon R, Manohar K, Sathyanarayana Raju Y, Madharia A, Chakravarty J, Chaubey M, Bandaru R K, Ali Mirza M, Kataria S, Sharma P, Ghosh S, Hazra A,
Affiliation:
1. From the Indian Council of Medical Research , New Delhi, India 2. Postgraduate Institute of Medical Education & Research , Chandigarh, India 3. Gandhi Medical College , Telangana, India 4. All Indian Institute of Medical Sciences , Jodhpur, Rajasthan, India 5. All Indian Institute of Medical Sciences , Raipur, Chhattisgarh, India 6. College of Medicine, Sagore Dutta Hospital , Kolkata, West Bengal, India 7. Medical College , Kolkata, West Bengal, India 8. Infectious Disease and Beliaghata General Hospital , Kolkata, West Bengal, India 9. Christian Medical College , Ludhiana, Punjab, India 10. Smt. NHL, Municipal Medical College , Ahmedabad, Gujarat, India 11. CIMS Hospital , Ahmedabad, Gujarat, India 12. All India Institute of Medical Sciences , Bhubaneswar, Odisha, India 13. All India Institute of Medical Sciences , Bhopal, Madhya Pradesh, India 14. National Institute of Medical Statistics, Indian Council of Medical Research , Delhi, India
Abstract
AbstractObjectivesThis study aims to describe the demographic and clinical profile and ascertain the determinants of outcome among hospitalized coronavirus disease 2019 (COVID-19) adult patients enrolled in the National Clinical Registry for COVID-19 (NCRC).MethodsNCRC is an on-going data collection platform operational in 42 hospitals across India. Data of hospitalized COVID-19 patients enrolled in NCRC between 1st September 2020 to 26th October 2021 were examined.ResultsAnalysis of 29 509 hospitalized, adult COVID-19 patients [mean (SD) age: 51.1 (16.2) year; male: 18 752 (63.6%)] showed that 15 678 (53.1%) had at least one comorbidity. Among 25 715 (87.1%) symptomatic patients, fever was the commonest symptom (72.3%) followed by shortness of breath (48.9%) and dry cough (45.5%). In-hospital mortality was 14.5% (n = 3957). Adjusted odds of dying were significantly higher in age group ≥60 years, males, with diabetes, chronic kidney diseases, chronic liver disease, malignancy and tuberculosis, presenting with dyspnoea and neurological symptoms. WHO ordinal scale 4 or above at admission carried the highest odds of dying [5.6 (95% CI: 4.6–7.0)]. Patients receiving one [OR: 0.5 (95% CI: 0.4–0.7)] or two doses of anti-SARS CoV-2 vaccine [OR: 0.4 (95% CI: 0.3–0.7)] were protected from in-hospital mortality.ConclusionsWHO ordinal scale at admission is the most important independent predictor for in-hospital death in COVID-19 patients. Anti-SARS-CoV2 vaccination provides significant protection against mortality.
Funder
Indian Council of Medical Research
Publisher
Oxford University Press (OUP)
Cited by
5 articles.
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