Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis

Author:

Cooke G1,Kamal I23,Strengert M2,Hams E45,Mawhinney L4,Tynan A4,O’Reilly C4,O’Dwyer D N23,Kunkel S L6,Knaus U G2,Shields D C7,Moller D R8,Bowie A G9,Fallon P G45,Hogaboam C M6,Armstrong M E4,Donnelly S C410

Affiliation:

1. Department of Applied Sciences, Institute of Technology Tallaght, Tallaght, Dublin 24, Ireland

2. School of Medicine and Medical Science, College of Life Sciences, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland

3. National Pulmonary Fibrosis Referral Centre at St. Vincent’s University Hospital, Elm Park, Dublin 4, Ireland

4. School of Medicine, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland

5. National Children’s Research Centre, Our Lady’s Children’s Hospital Crumlin, Dublin 12, Ireland

6. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA

7. UCD Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin 4, Ireland

8. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA

9. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland

10. Department of Clinical Medicine, Trinity Centre for Health Sciences, Tallaght Hospital, Tallaght, Dublin 24, Ireland

Funder

Health Research Board

Publisher

Oxford University Press (OUP)

Subject

General Medicine

Reference35 articles.

1. Sarcoidosis;Iannuzzi;N Engl J Med,2007

2. Joint statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999;Statement on Sarcoidosis;Am J Respir Crit Care Med,1999

3. The frequency of sarcoidosis in Finland and Hokkaido, Japan. A comparative epidemiological study;Pietinalho;Sarcoidosis,1995

4. Etiologies of sarcoidosis;Chen;Clin Rev Allergy Immunol,2015

5. Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis;Moller;J Immunol,1996

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