Total bone mineral density is inversely associated with stroke: a family osteoporosis cohort study in rural China

Author:

Zhu B1,Yang J2,Zhou Z3,Ling X1,Cheng N2,Wang Z3,Liu L3,Huang X4,Song Y25,Wang B56,Qin X7,Zalloua P8,Xu X P37,Yang L1,Zhao Z1

Affiliation:

1. From the Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

2. State Key Laboratory of Natural Medicines, Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing 210009, China

3. Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China

4. Department of Cardiovascular Medicine, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China

5. Institute of Biomedicine, Anhui Medical University, Hefei 230022, China

6. Shenzhen Evergreen Medical Institute, Shenzhen 518057, China

7. National Clinical Research Study Center for Kidney Disease; the State Key Laboratory for Organ Failure Research; Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

8. School of Medicine, Lebanese American University, PO Box 36, Byblos, Lebanon

Abstract

Summary Background The relationship of osteoporosis and stroke is still not fully clarified. Apart from the well-known risk factors for stroke, bone mineral density (BMD) has gained more interest in recent years. Aim To further elucidate the relationship between BMD and stroke risk, a prospective cohort study in the Chinese rural population was conducted. Design Retrospective analysis of a family osteoporosis cohort. Methods Our subjects were selected from an osteoporosis cohort conducted in Anqing, China. All participants underwent a questionnaire assessment, clinical examinations and laboratory assessments. During the follow-up period, the number of people who had a stroke was recorded. Generalized estimating equation regression analysis was performed to determine the significance of the association between BMD and stroke. Results A total of 17868 people were included. A two-way interaction test of sex and BMD on stroke was significant (P = 0.002). There was a significant difference in BMD and stroke morbidity in the male group (P = 0.003). When BMD was assessed as quartiles and the lowest quartile was used as reference, a significantly lower risk for stroke was observed in Q2–4. Notably, no significant difference was observed in female participants with adjusted odds ratio (P > 0.05). The P-value for interaction was calculated. The body mass index (P = 0.014) and waist-to-hip ratio (P = 0.027) were found to be significantly associated with BMD and stroke risk in female participants. Conclusions In Chinese rural areas, total BMD may negatively correlated with stroke, especially in men.

Funder

Beijing Municipal Administration of Hospitals

the National Key Research and Development Program

Science and Technology Planning Project of Guangzhou

Science, Technology and Innovation Committee of Shenzhen

the Economic, Trade and Information Commission of Shenzhen Municipality

the National Natural Science Foundation of China

Jiangxi Outstanding Person Foundation

Major projects of the Science and Technology Department, Jiangxi

Publisher

Oxford University Press (OUP)

Subject

General Medicine

Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3