1. Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital , Liverpool, UK
2. Department of Clinical Medicine, Danish Center for Health Services Research, Aalborg University , Aalborg, Denmark
3. Department of General and Specialized Surgery, Sapienza University of Rome , Rome, Italy
4. Department of Translational and Precision Medicine, Sapienza University of Rome , Rome, Italy
5. Stroke Division, Department of Medicine for Older People, Whiston Hospital, St Helens and Knowsley Teaching Hospitals NHS Trust , Prescot, UK