Neurological complications of COVID-19

Author:

Dai X1ORCID,Cao X2,Jiang Q2,Wu B1,Lou T2,Shao Y2,Hu Y1,Lan Q3

Affiliation:

1. From the Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University , Hefei 230022, P. R. China

2. Department of Clinical Medicine, The First Clinical College of Anhui Medical University , Hefei 230032, P. R. China

3. Department of Neurosurgery, The Second Affiliated Hospital of Soochow University , Suzhou 215004, P. R. China

Abstract

Abstract Corona Virus Disease 2019 (COVID-19) has caused several pandemic peaks worldwide due to its high variability and infectiousness, and COVID-19 has become a long-standing global public health problem. There is growing evidence that severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) frequently causes multi-organ injuries and more severe neurological manifestations. Therefore, increased awareness of possible neurological complications is beneficial in preventing and mitigating the impact of long-term sequelae and improving the prognostic outcome of critically ill patients with COVID-19. Here, we review the main pathways of SARS-CoV-2 neuroinvasion and the potential mechanisms causing neurological damage. We also discuss in detail neurological complications, aiming to provide cutting-edge basis for subsequent related basic research and clinical studies of diagnosis and treatment.

Funder

Anhui Provincial Natural Science Foundation

Anhui Medical University

Scientific Research Fund Project of Anhui Medical University

Natural Science Research Project of Colleges

Universities in Anhui Province

Publisher

Oxford University Press (OUP)

Subject

General Medicine

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