Affiliation:
1. Department of Biomedical Informatics, MOE Key Lab of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University, Beijing 100191, China
Abstract
Abstract
It is well-known that some microRNAs (miRNAs) are more important than the others for life, hinting the wide range of miRNA in essentiality or importance. Functional enrichment analysis is a quite pervasive method to dig out the underlying biological pathway for a given gene list and several tools of miRNA set enrichment analysis have been developed. However, all those tools treat each miRNA equally and neglect the importance score of miRNA itself, which could be an obstacle to seek more insightful biological processes for researchers. Here, we developed wTAM, a tool for annotation of weighted human miRNAs, introducing the miRNA importance scores into enrichment analysis. In addition, the annotation repository has been enlarged comparing to TAM. Finally, the case study demonstrated the availability and flexibility of wTAM.
Availability and implementation
wTAM is freely available at http://www.cuilab.cn/wtam/.
Supplementary information
Supplementary data are available at Bioinformatics Advances online.
Funder
National Key R&D Program
PKU-Baidu Fund
Natural Science Foundation of China
Peking University Basic Research Program
Publisher
Oxford University Press (OUP)
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