A conserved loop–wedge motif moderates reaction site search and recognition by FEN1
Author:
Affiliation:
1. Centre for Chemical Biology, Department of Chemistry, Krebs Institute, University of Sheffield, Brook Hill, Sheffield S3 7HF, UK
Funder
Biotechnology and Biological Sciences Research Council
Publisher
Oxford University Press (OUP)
Subject
Genetics
Link
http://academic.oup.com/nar/article-pdf/46/15/7858/25690294/gky506.pdf
Reference60 articles.
1. Flap endonuclease 1;Balakrishnan;Annu. Rev. Biochem.,2013
2. Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1);Klungland;EMBO J.,1997
3. Processing ribonucleotides incorporated during eukaryotic DNA replication;Williams;Nat. Rev. Cell Mol. Biol.,2016
4. Kinetics of endogenous mouse FEN1 in base excision repair;Kleppa;Nucleic Acids Res.,2012
5. Haploinsufficiency of flap endonuclease (FEN1) leads to rapid tumor progression;Kucherlapati;Proc. Natl. Acad. Sci. U.S.A.,2002
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