Emotion recognition in relation to tumor characteristics in patients with low-grade glioma

Author:

Siebenga Femke F12,van der Weide Hiska L3,Gelmers Floor12,Rakers Sandra E12,Kramer Miranda C A3,van der Hoorn Anouk4,Enting Roelien H2,Bosma Ingeborg2,Groen Rob J M56,Jeltema Hanne-Rinck5,Wagemakers Michiel5,Spikman Jacoba M12,Buunk Anne M1

Affiliation:

1. Department of Neurology, Unit of Neuropsychology, University of Groningen, University Medical Center Groningen , Groningen , The Netherlands

2. Department of Neurology, University of Groningen, University Medical Center Groningen , Groningen , The Netherlands

3. Department of Radiation Oncology, University of Groningen, University Medical Center Groningen , Groningen , The Netherlands

4. Department of Radiology, University of Groningen, University Medical Center Groningen , Groningen , The Netherlands

5. Department of Neurosurgery, University Medical Center Groningen, University of Groningen

6. Department of Neurosurgery, Faculty of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital , Surabaya , Indonesia

Abstract

Abstract Background Patients with low-grade gliomas (LGG) treated with surgery, generally function well and have a favorable prognosis. However, LGG can affect neurocognitive functioning. To date, little is known about social cognition (SC) in these patients, although impaired SC is related to social-behavioral problems and poor societal participation. Frontal brain areas are important for SC and LGG frequently have a frontal location. Therefore, the aim of the present study was to investigate whether emotion recognition, a key component of SC, was impaired, and related to general cognition, tumor location, laterality, tumor volume, and histopathological characteristics in patients with LGG, postsurgery, and before start of adjuvant therapy. Methods A total of 121 patients with LGG were matched with 169 healthy controls (HC). Tumor location [including (frontal) subregions; insula, anterior cingulate cortex, lateral prefrontal cortex (LPFC), orbitofrontal-ventromedial PFC] and tumor volume were determined on MRI scans. Emotion recognition was measured with the Ekman 60 faces test of the Facial Expressions of Emotion-Stimuli and Tests (FEEST). Results Patients with LGG performed significantly lower on the FEEST than HC, with 33.1% showing impairment compared to norm data. Emotion recognition was not significantly correlated to frontal tumor location, laterality, and histopathological characteristics, and significantly but weakly with general cognition and tumor volume. Conclusions Emotion recognition is impaired in patients with LGG but not (strongly) related to specific tumor characteristics or general cognition. Hence, measuring SC with individual neuropsychological assessment of these patients is crucial, irrespective of tumor characteristics, to inform clinicians about possible impairments, and consequently offer appropriate care.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Neurology (clinical),Oncology

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