Global survival trends for brain tumors, by histology: analysis of individual records for 556,237 adults diagnosed in 59 countries during 2000–2014 (CONCORD-3)
Author:
Girardi Fabio123ORCID, Matz Melissa1, Stiller Charles4, You Hui5, Marcos Gragera Rafael6, Valkov Mikhail Y7, Bulliard Jean-Luc89, De Prithwish10, Morrison David11, Wanner Miriam12, O’Brian David K13, Saint-Jacques Nathalie14, Coleman Michel P12ORCID, Allemani Claudia1ORCID, Bouzbid S, Hamdi-Chérif M, Kara L, Meguenni K, Regagba D, Bayo S, Cheick Bougadari T, Manraj S S, Bendahhou K, Ladipo A, Ogunbiyi O J, Somdyala N I M, Chaplin M A, Moreno F, Calabrano G H, Espinola S B, Carballo Quintero B, Fita R, Laspada W D, Ibañez S G, Lima C A, Da Costa A Mafra, De Souza P C F, Chaves J, Laporte C A, Curado M P, de Oliveira J C, Veneziano C L A, Veneziano D B, Almeida A B M, Latorre M R D O, Rebelo M S, Santos M O, Azevedo e Silva G, Galaz J C, Aparicio Aravena M, Sanhueza Monsalve J, Herrmann D A, Vargas S, Herrera V M, Uribe C J, Bravo L E, Garcia L S, Arias-Ortiz N E, Morantes D, Jurado D M, Yépez Chamorro M C, Delgado S, Ramirez M, Galán Alvarez Y H, Torres P, Martínez-Reyes F, Jaramillo L, Quinto R, Castillo J, Mendoza M, Cueva P, Yépez J G, Bhakkan B, Deloumeaux J, Joachim C, Macni J, Carrillo R, Shalkow Klincovstein J, Rivera Gomez R, Perez P, Poquioma E, Tortolero-Luna G, Zavala D, Alonso R, Barrios E, Eckstrand A, Nikiforuk C, Woods R R, Noonan G, Turner D, Kumar E, Zhang B, Dowden J J, Doyle G P, Saint-Jacques N, Walsh G, Anam A, De P, McClure C A, Vriends K A, Bertrand C, Ramanakumar A V, Davis L, Kozie S, Freeman T, George J T, Avila R M, O’Brien D K, Holt A, Almon L, Kwong S, Morris C, Rycroft R, Mueller L, Phillips C E, Brown H, Cromartie B, Ruterbusch J, Schwartz A G, Levin G M, Wohler B, Bayakly R, Ward K C, Gomez S L, McKinley M, Cress R, Davis J, Hernandez B, Johnson C J, Morawski B M, Ruppert L P, Bentler S, Charlton M E, Huang B, Tucker T C, Deapen D, Liu L, Hsieh M C, Wu X C, Schwenn M, Stern K, Gershman S T, Knowlton R C, Alverson G, Weaver T, Desai J, Rogers D B, Jackson-Thompson J, Lemons D, Zimmerman H J, Hood M, Roberts-Johnson J, Hammond W, Rees J R, Pawlish K S, Stroup A, Key C, Wiggins C, Kahn A R, Schymura M J, Radhakrishnan S, Rao C, Giljahn L K, Slocumb R M, Dabbs C, Espinoza R E, Aird K G, Beran T, Rubertone J J, Slack S J, Oh J, Janes T A, Schwartz S M, Chiodini S C, Hurley D M, Whiteside M A, Rai S, Williams M A, Herget K, Sweeney C, Kachajian J, Keitheri Cheteri M B, Migliore Santiago P, Blankenship S E, Conaway J L, Borchers R, Malicki R, Espinoza J, Grandpre J, Weir H K, Wilson R, Edwards B K, Mariotto A, Rodriguez-Galindo C, Wang N, Yang L, Chen J S, Zhou Y, He Y T, Song G H, Gu X P, Mei D, Mu H J, Ge H M, Wu T H, Li Y Y, Zhao D L, Jin F, Zhang J H, Zhu F D, Junhua Q, Yang Y L, Jiang C X, Biao W, Wang J, Li Q L, Yi H, Zhou X, Dong J, Li W, Fu F X, Liu S Z, Chen J G, Zhu J, Li Y H, Lu Y Q, Fan M, Huang S Q, Guo G P, Zhaolai H, Wei K, Chen W Q, Wei W, Zeng H, Demetriou A V, Mang W K, Ngan K C, Kataki A C, Krishnatreya M, Jayalekshmi P A, Sebastian P, George P S, Mathew A, Nandakumar A, Malekzadeh R, Roshandel G, Keinan-Boker L, Silverman B G, Ito H, Koyanagi Y, Sato M, Tobori F, Nakata I, Teramoto N, Hattori M, Kaizaki Y, Moki F, Sugiyama H, Utada M, Nishimura M, Yoshida K, Kurosawa K, Nemoto Y, Narimatsu H, Sakaguchi M, Kanemura S, Naito M, Narisawa R, Miyashiro I, Nakata K, Mori D, Yoshitake M, Oki I, Fukushima N, Shibata A, Iwasa K, Ono C, Matsuda T, Nimri O, Jung K W, Won Y J, Alawadhi E, Elbasmi A, Ab Manan A, Adam F, Nansalmaa E, Tudev U, Ochir C, Al Khater A M, El Mistiri M M, Lim G H, Teo Y Y, Chiang C J, Lee W C, Buasom R, Sangrajrang S, Suwanrungruang K, Vatanasapt P, Daoprasert K, Pongnikorn D, Leklob A, Sangkitipaiboon S, Geater S L, Sriplung H, Ceylan O, Kög I, Dirican O, Köse T, Gurbuz T, Karaşahin F E, Turhan D, Aktaş U, Halat Y, Eser S, Yakut C I, Altinisik M, Cavusoglu Y, Türkköylü A, Üçüncü N, Hackl M, Zborovskaya A A, Aleinikova O V, Henau K, Van Eycken L, Atanasov T Y, Valerianova Z, Šekerija M, Dušek L, Zvolský M, Steinrud Mørch L, Storm H, Wessel Skovlund C, Innos K, Mägi M, Malila N, Seppä K, Jégu J, Velten M, Cornet E, Troussard X, Bouvier A M, Guizard A V, Bouvier V, Launoy G, Dabakuyo Yonli S, Poillot M L, Maynadié M, Mounier M, Vaconnet L, Woronoff A S, Daoulas M, Robaszkiewicz M, Clavel J, Poulalhon C, Desandes E, Lacour B, Baldi I, Amadeo B, Coureau G, Monnereau A, Orazio S, Audoin M, D’Almeida T C, Boyer S, Hammas K, Trétarre B, Colonna M, Delafosse P, Plouvier S, Cowppli-Bony A, Molinié F, Bara S, Ganry O, Lapôtre-Ledoux B, Daubisse-Marliac L, Bossard N, Uhry Z, Estève J, Stabenow R, Wilsdorf-Köhler H, Eberle A, Luttmann S, Löhden I, Nennecke A L, Kieschke J, Sirri E, Justenhoven C, Reinwald F, Holleczek B, Eisemann N, Katalinic A, Asquez R A, Kumar V, Petridou E, Ólafsdóttir E J, Tryggvadóttir L, Murray D E, Walsh P M, Sundseth H, Harney M, Mazzoleni G, Vittadello F, Coviello E, Cuccaro F, Galasso R, Sampietro G, Giacomin A, Magoni M, Ardizzone A, D’Argenzio A, Di Prima A A, Ippolito A, Lavecchia A M, Sutera Sardo A, Gola G, Ballotari P, Giacomazzi E, Ferretti S, Dal Maso L, Serraino D, Celesia M V, Filiberti R A, Pannozzo F, Melcarne A, Quarta F, Andreano A, Russo A G, Carrozzi G, Cirilli C, Cavalieri d’Oro L, Rognoni M, Fusco M, Vitale M F, Usala M, Cusimano R, Mazzucco W, Michiara M, Sgargi P, Boschetti L, Marguati S, Chiaranda G, Seghini P, Maule M M, Merletti F, Spata E, Tumino R, Mancuso P, Cassetti T, Sassatelli R, Falcini F, Giorgetti S, Caiazzo A L, Cavallo R, Piras D, Bella F, Madeddu A, Fanetti A C, Maspero S, Carone S, Mincuzzi A, Candela G, Scuderi T, Gentilini M A, Rizzello R, Rosso S, Caldarella A, Intrieri T, Bianconi F, Contiero P, Tagliabue G, Rugge M, Zorzi M, Beggiato S, Brustolin A, Gatta G, De Angelis R, Vicentini M, Zanetti R, Stracci F, Maurina A, Oniščuka M, Mousavi M, Steponaviciene L, Vincerževskienė I, Azzopardi M J, Calleja N, Siesling S, Visser O, Johannesen T B, Larønningen S, Trojanowski M, Macek P, Mierzwa T, Rachtan J, Rosińska A, Kępska K, Kościańska B, Barna K, Sulkowska U, Gebauer T, Łapińska J B, Wójcik-Tomaszewska J, Motnyk M, Patro A, Gos A, Sikorska K, Bielska-Lasota M, Didkowska J A, Wojciechowska U, Forjaz de Lacerda G, Rego R A, Carrito B, Pais A, Bento M J, Rodrigues J, Lourenço A, Mayer-da-Silva A, Coza D, Todescu A I, Valkov M Y, Gusenkova L, Lazarevich O, Prudnikova O, Vjushkov D M, Egorova A, Orlov A, Pikalova L V, Zhuikova L D, Adamcik J, Safaei Diba C, Zadnik V, Žagar T, De-La-Cruz M, Lopez-de-Munain A, Aleman A, Rojas D, Chillarón R J, Navarro A I M, Marcos-Gragera R, Puigdemont M, Rodríguez-Barranco M, Sánchez Perez M J, Franch Sureda P, Ramos Montserrat M, Chirlaque López M D, Sánchez Gil A, Ardanaz E, Guevara M, Cañete-Nieto A, Peris-Bonet R, Carulla M, Galceran J, Almela F, Sabater C, Khan S, Pettersson D, Dickman P, Staehelin K, Struchen B, Egger Hayoz C, Rapiti E, Schaffar R, Went P, Mousavi S M, Bulliard J-L, Maspoli-Conconi M, Kuehni C E, Redmond S M, Bordoni A, Ortelli L, Chiolero A, Konzelmann I, Rohrmann S, Wanner M, Broggio J, Rashbass J, Stiller C, Fitzpatrick D, Gavin A, Morrison D S, Thomson C S, Greene G, Huws D W, Grayson M, Rawcliffe H, Allemani C, Coleman M P, Di Carlo V, Girardi F, Matz M, Minicozzi P, Sanz N, Ssenyonga N, James D, Stephens R, Chalker E, Smith M, Gugusheff J, You H, Qin Li S, Dugdale S, Moore J, Philpot S, Pfeiffer R, Thomas H, Silva Ragaini B, Venn A J, Evans S M, Te Marvelde L, Savietto V, Trevithick R, Aitken J, Currow D, Fowler C, Lewis C,
Affiliation:
1. Cancer Survival Group, London School of Hygiene and Tropical Medicine , London , UK 2. Cancer Division, University College London Hospitals NHS Foundation Trust , London , UK 3. Division of Medical Oncology 2, Veneto Institute of Oncology IOV-IRCCS , Padua , Italy 4. National Cancer Registration and Analysis Service, Public Health England , London , UK 5. Cancer Information Analysis Unit, Cancer Institute NSW , St Leonards, New South Wales , Australia 6. Epidemiology Unit and Girona Cancer Registry, Catalan Institute of Oncology , Girona , Spain 7. Department of Radiology, Radiotherapy and Oncology, Northern State Medical University , Arkhangelsk , Russia 8. Centre for Primary Care and Public Health (Unisanté), University of Lausanne , Lausanne , Switzerland 9. Neuchâtel and Jura Tumour Registry , Neuchâtel , Switzerland 10. Surveillance and Cancer Registry, and Research Office, Clinical Institutes and Quality Programs, Ontario Health , Toronto, Ontario , Canada 11. Scottish Cancer Registry, Public Health Scotland , Edinburgh , UK 12. Cancer Registry Zürich, Zug, Schaffhausen and Schwyz, University Hospital Zürich , Zürich , Switzerland 13. Alaska Cancer Registry, Alaska Department of Health and Social Services , Anchorage, Alaska , USA 14. Department of Medicine and Community Health and Epidemiology, Centre for Clinical Research, Dalhousie University , Halifax, Nova Scotia , Canada
Abstract
Abstract
Background
Survival is a key metric of the effectiveness of a health system in managing cancer. We set out to provide a comprehensive examination of worldwide variation and trends in survival from brain tumors in adults, by histology.
Methods
We analyzed individual data for adults (15–99 years) diagnosed with a brain tumor (ICD-O-3 topography code C71) during 2000–2014, regardless of tumor behavior. Data underwent a 3-phase quality control as part of CONCORD-3. We estimated net survival for 11 histology groups, using the unbiased nonparametric Pohar Perme estimator.
Results
The study included 556,237 adults. In 2010–2014, the global range in age-standardized 5-year net survival for the most common sub-types was broad: in the range 20%–38% for diffuse and anaplastic astrocytoma, from 4% to 17% for glioblastoma, and between 32% and 69% for oligodendroglioma. For patients with glioblastoma, the largest gains in survival occurred between 2000–2004 and 2005–2009. These improvements were more noticeable among adults diagnosed aged 40–70 years than among younger adults.
Conclusions
To the best of our knowledge, this study provides the largest account to date of global trends in population-based survival for brain tumors by histology in adults. We have highlighted remarkable gains in 5-year survival from glioblastoma since 2005, providing large-scale empirical evidence on the uptake of chemoradiation at population level. Worldwide, survival improvements have been extensive, but some countries still lag behind. Our findings may help clinicians involved in national and international tumor pathway boards to promote initiatives aimed at more extensive implementation of clinical guidelines.
Funder
Children with Cancer UK American Cancer Society Centers for Disease Control and Prevention Swiss Cancer Research Foundation Swiss Cancer League Institut National du Cancer Rossy Family Foundation US National Cancer Institute Susan G Komen Foundation
Publisher
Oxford University Press (OUP)
Subject
Cancer Research,Neurology (clinical),Oncology
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