Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location

Author:

Karremann Michael,Gielen Gerrit H,Hoffmann Marion,Wiese Maria,Colditz Niclas,Warmuth-Metz Monika,Bison Brigitte,Claviez Alexander,van Vuurden Dannis G,von Bueren André O,Gessi Marco,Kühnle Ingrid,Hans Volkmar H,Benesch Martin,Sturm Dominik,Kortmann Rolf-Dieter,Waha Andreas,Pietsch Torsten,Kramm Christof M

Funder

Deutsche Kinderkrebsstiftung

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Neurology (clinical),Oncology

Reference40 articles.

1. Pediatric high-grade glioma: biologically and clinically in need of new thinking;Neuro Oncol,2017

2. Diffuse midline glioma, H3 K27M-mutant,2016

3. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas;Cancer Cell,2013

4. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma;Science,2013

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