Feasibility of real-time molecular profiling for patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation—the NCT Neuro Master Match (N2M2) pilot study

Author:

Pfaff Elke12,Kessler Tobias34,Balasubramanian Gnana Prakash156,Berberich Anne34,Schrimpf Daniel78,Wick Antje4,Debus Jürgen9101112,Unterberg Andreas13,Bendszus Martin14,Herold-Mende Christel15,Capper David16,Schenkel Irini17,Eisenmenger Andreas17,Dettmer Susan17,Brors Benedikt5618,Platten Michael1920,Pfister Stefan M12,von Deimling Andreas78,Jones David T W1,Wick Wolfgang34,Sahm Felix78

Affiliation:

1. Division of Pediatric Neuro-oncology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany

2. Department of Pediatric Oncology, Hematology, Immunology, and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany

3. Clinical Cooperation Unit Neuro-oncology, DKTK, DKFZ, Heidelberg, Germany

4. Department of Neurology and Neuro-oncology Program, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Heidelberg, Germany

5. Division of Applied Bioinformatics, DKFZ, Heidelberg, Germany

6. National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany

7. Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany

8. Clinical Cooperation Unit Neuropathology, DKTK, DKFZ, Heidelberg, Germany

9. Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany

10. National Center for Radiation Oncology, Heidelberg Institute for Radiation Oncology, Heidelberg, Germany

11. Clinical Cooperation Unit Radiation Oncology, DKFZ, Heidelberg, Germany

12. Heidelberg Ion-Beam Therapy Center, Heidelberg, Germany

13. Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany

14. Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany

15. Division of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany

16. Department of Neuropathology, Charité Universitätsmedizin Berlin, Berlin, Germany

17. NCT Trial Center, National Center for Tumor Diseases, DKFZ, Heidelberg, Germany

18. DKTK, Heidelberg, Germany

19. Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, DKTK, DKFZ, Heidelberg, Germany

20. Department of Neurology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

Funder

DKFZ-Heidelberg Center for Personalized Oncology

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Neurology (clinical),Oncology

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