Volumetric response quantified using T1 subtraction predicts long-term survival benefit from cabozantinib monotherapy in recurrent glioblastoma

Author:

Ellingson Benjamin M12ORCID,Aftab Dana T3,Schwab Gisela M3,Hessel Colin3,Harris Robert J14,Woodworth Davis C14,Leu Kevin14,Chakhoyan Ararat14,Raymond Catalina14,Drappatz Jan5,de Groot John6,Prados Michael D7,Reardon David A8,Schiff David9,Chamberlain Marc10,Mikkelsen Tom11,Desjardins Annick12,Holland Jaymes3,Ping Jerry3,Weitzman Ron3,Wen Patrick Y8,Cloughesy Timothy F213

Affiliation:

1. UCLA Brain Tumor Imaging Laboratory, Center for Computer Vision and Imaging Biomarkers, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California

2. UCLA Neuro-Oncology Program, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California

3. Exelixis, South San Francisco, California

4. Departments of Radiological Sciences and Psychiatry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California

5. Department of Neurology and Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

6. Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas

7. Department of Neurosurgery, University of California San Francisco (UCSF), San Francisco, California

8. Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts

9. Neuro-Oncology Center, University of Virginia Health System, Charlottesville, Virginia

10. Department of Neurology, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington

11. Henry Ford Health System, Detroit, Michigan

12. Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina

13. Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California

Funder

American Cancer Society Research Scholar

UCLA SPORE in Brain

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Neurology (clinical),Oncology

Reference48 articles.

1. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2006-2010;Ostrom;Neuro Oncol,2013

2. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma;Stupp;N Engl J Med,2005

3. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial;Stupp;Lancet Oncol,2009

4. Inhibition of hypoxia inducible factor-1alpha (HIF-1alpha) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas;Jensen;J Neurooncol,2006

5. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo;Plate;Nature,1992

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