Enhancing neuro-oncology care through equity-driven applications of artificial intelligence

Author:

Mehari Mulki1,Sibih Youssef1,Dada Abraham1,Chang Susan M2,Wen Patrick Y3,Molinaro Annette M1ORCID,Chukwueke Ugonma N3,Budhu Joshua A4ORCID,Jackson Sadhana5ORCID,McFaline-Figueroa J Ricardo3,Porter Alyx6ORCID,Hervey-Jumper Shawn L1ORCID

Affiliation:

1. Department of Neurosurgery, University of California, San Francisco , San Francisco, California , USA

2. Division of Neuro-Oncology, University of California San Francisco and Weill Institute for Neurosciences , San Francisco, California , USA

3. Center for Neuro-Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School , Boston, Massachusetts , USA

4. Department of Neurology, Memorial Sloan Kettering Cancer Center, Department of Neurology, Weill Cornell Medicine, Joan & Sanford I. Weill Medical College of Cornell University , New York, New York , USA

5. Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health , Bethesda, Maryland , USA

6. Division of Neuro-Oncology, Department of Neurology, Mayo Clinic , Phoenix, Arizona , USA

Abstract

Abstract The disease course and clinical outcome for brain tumor patients depend not only on the molecular and histological features of the tumor but also on the patient’s demographics and social determinants of health. While current investigations in neuro-oncology have broadly utilized artificial intelligence (AI) to enrich tumor diagnosis and more accurately predict treatment response, postoperative complications, and survival, equity-driven applications of AI have been limited. However, AI applications to advance health equity in the broader medical field have the potential to serve as practical blueprints to address known disparities in neuro-oncologic care. In this consensus review, we will describe current applications of AI in neuro-oncology, postulate viable AI solutions for the most pressing inequities in neuro-oncology based on broader literature, propose a framework for the effective integration of equity into AI-based neuro-oncology research, and close with the limitations of AI.

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

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