The histology of brain tumors for 67 331 children and 671 085 adults diagnosed in 60 countries during 2000-2014: a global, population-based study (CONCORD-3)
Author:
Girardi Fabio12ORCID, Rous Brian3, Stiller Charles A3, Gatta Gemma4, Fersht Naomi2, Storm Hans H5, Rodrigues Jessica R6, Herrmann Christian7, Marcos-Gragera Rafael8, Peris-Bonet Rafael9, Valkov Mikhail10, Weir Hannah K11, Woods Ryan R12, You Hui13, Cueva Patricia A14, De Prithwish15, Di Carlo Veronica1ORCID, Johannesen Tom Børge16, Lima Carlos A17, Lynch Charles F18, Coleman Michel P12, Allemani Claudia1ORCID, Bouzbid S, Hamdi-Chérif M, Zaidi Z, Meguenni K, Regagba D, Bayo S, Cheick Bougadari T, Manraj S S, Bendahhou K, Ladipo A, Ogunbiyi O J, Ramaliba T, Somdyala N I M, Chaplin M A, Moreno F, Calabrano G H, Espinola S B, Carballo Quintero B, Fita R, Laspada W D, Ibañez S G, Lima C A, Mafra da Costa A, De Souza P C F, Del Pino K, Laporte C, Curado M P, de Oliveira J C, Veneziano C L A, Veneziano D B, Latorre M R D O, Tanaka L F, Rebelo M S, Santos M O, Azevedo e Silva G, Galaz J C, Aparicio Aravena M, Sanhueza Monsalve J, Herrmann D A, Vargas S, Herrera V M, Uribe C J, Bravo L E, Garcia L S, Arias-Ortiz N E, Morantes D, Jurado D M, Yépez Chamorro M C, Delgado S, Ramirez M, Galán Alvarez Y H, Torres P, Martínez-Reyes F, Jaramillo L, Quinto R, Castillo J, Mendoza M, Cueva P, Yépez J G, Bhakkan B, Deloumeaux J, Joachim C, Macni J, Carrillo R, Shalkow Klincovstein J, Rivera Gomez R, Perez P, Poquioma E, Tortolero-Luna G, Zavala D, Alonso R, Barrios E, Eckstrand A, Nikiforuk C, Woods R R, Noonan G, Turner D, Kumar E, Zhang B, McCrate F R, Ryan S, MacIntyre M, Saint-Jacques N, Anam A, De P, McClure C A, Vriends K A, Bertrand C, Latreille J, Kozie S, Stuart-Panko H, Freeman T, George J T, Avila R M, O’Brien D K, Holt A, Almon L, Kwong S, Morris C, Rycroft R, Mueller L, Phillips C E, Brown H, Cromartie B, Schwartz A G, Vigneau F, Levin G M, Wohler B, Bayakly R, Ward K C, Gomez S L, McKinley M, Cress R, Green M D, Miyagi K, Johnson C J, Ruppert L P, Bentler S, Charlton M E, Huang B, Tucker T C, Deapen D, Liu L, Hsieh M C, Wu X C, Schwenn M, Stern K, Gershman S T, Knowlton R C, Alverson G, Weaver T, Bushhouse S, Rogers D B, Jackson-Thompson J, Lemons D, Zimmerman H J, Hood M, Roberts-Johnson J, Riddle B, Rees J R, Pawlish K S, Stroup A, Key C, Wiggins C, Kahn A R, Schymura M J, Radhakrishnan S, Rao C, Giljahn L K, Slocumb R M, Feld A, Aird K G, Beran T, Rubertone J J, Slack S J, Oh J, Janes T A, Schwartz S M, Chiodini S, Hurley D M, Whiteside M A, Rai S, Williams M A, Herget K, Sweeney C, Johnson A T, Keitheri Cheteri M B, Migliore Santiago P, Blankenship S E, Farley S, Borchers R, Malicki R, Espinoza J, Grandpre J, Weir H K, Wilson R, Edwards B K, Mariotto A, Wang N, Yang L, Chen J S, Zhou Y, He Y T, Song G H, Gu X P, Mei D, Mu H J, Ge H M, Wu T H, Li Y Y, Zhao D L, Jin F, Zhang J H, Zhu F D, Junhua Q, Yang Y L, Jiang C X, Biao W, Wang J, Li Q L, Yi H, Zhou X, Dong J, Li W, Fu F X, Liu S Z, Chen J G, Zhu J, Li Y H, Lu Y Q, Fan M, Huang S Q, Guo G P, Zhaolai H, Wei K, Chen W-Q, Wei W, Zeng H, Demetriou A V, Mang W K, Ngan K C, Kataki A C, Krishnatreya M, Jayalekshmi P A, Sebastian P, George P S, Mathew A, Nandakumar A, Malekzadeh R, Roshandel G, Keinan-Boker L, Silverman B G, Koyanagi Y, Ito H, Sato M, Tobori F, Nakata I, Teramoto N, Hattori M, Kaizaki Y, Moki F, Sugiyama H, Utada M, Nishimura M, Yoshida K, Kurosawa K, Nemoto Y, Narimatsu H, Sakaguchi M, Kanemura S, Naito M, Narisawa R, Miyashiro I, Nakata K, Maeda A, Sato S, Oki I, Fukushima N, Shibata A, Iwasa K, Ono C, Matsuda T, Nimri O, Jung K W, Won Y J, Alawadhi E, Elbasmi A, Ab Manan A, Adam F, Nansalmaa E, Tudev U, Ochir C, Al Khater A M, El Mistiri M M, Lim G H, Teo Y Y, Chiang C J, Lee W C, Buasom R, Sangrajrang S, Suwanrungruang K, Vatanasapt P, Daoprasert K, Pongnikorn D, Leklob A, Sangkitipaiboon S, Geater S L, Sriplung H, Ceylan O, Kög I, Dirican O, Köse T, Gurbuz T, Karaşahin F E, Turhan D, Aktaş U, Halat Y, Eser S, Yakut C I, Altinisik M, Cavusoglu Y, Türkköylü A, Üçüncü N, Hackl M, Zborovskaya A A, Aleinikova O V, Henau K, Van Eycken L, Valerianova Z, Yordanova M R, Šekerija M, Dušek L, Zvolský M, Steinrud Mørch L, Storm H, Wessel Skovlund C, Innos K, Mägi M, Malila N, Seppä K, Jégu J, Velten M, Cornet E, Troussard X, Bouvier A M, Guizard A V, Bouvier V, Launoy G, Arveux P, Maynadié M, Mounier M, Woronoff A S, Daoulas M, Robaszkiewicz M, Clavel J, Goujon S, Lacour B, Baldi I, Pouchieu C, Amadeo B, Coureau G, Orazio S, Monnereau A, Preux P M, Rharbaoui F, Marrer E, Trétarre B, Colonna M, Delafosse P, Plouvier S, Cowppli-Bony A, Molinié F, Bara S, Ganry O, Lapôtre-Ledoux B, Grosclaude P, Bossard N, Uhry Z, Estève J, Stabenow R, Wilsdorf-Köhler H, Eberle A, Luttmann S, Löhden I, Nennecke A L, Kieschke J, Sirri E, Justenhoven C, Zeissig S R, Holleczek B, Eisemann N, Katalinic A, Asquez R A, Kumar V, Petridou E, Ólafsdóttir E J, Tryggvadóttir L, Clough-Gorr K, Walsh P M, Sundseth H, Mazzoleni G, Vittadello F, Coviello E, Cuccaro F, Galasso R, Sampietro G, Giacomin A, Magoni M, Ardizzone A, D’Argenzio A, Castaing M, Grosso G, Lavecchia A M, Sutera Sardo A, Gola G, Gatti L, Ricci P, Ferretti S, Dal Maso L, Serraino D, Celesia M V, Filiberti R A, Pannozzo F, Melcarne A, Quarta F, Andreano A, Russo A G, Carrozzi G, Cirilli C, Cavalieri d’Oro L, Rognoni M, Fusco M, Vitale M F, Usala M, Cusimano R, Mazzucco W, Michiara M, Sgargi P, Boschetti L, Chiaranda G, Seghini P, Maule M M, Merletti F, Tumino R, Mancuso P, Vicentini M, Cassetti T, Sassatelli R, Falcini F, Giorgetti S, Caiazzo A L, Cavallo R, Cesaraccio R, Pirino D R, Bella F, Madeddu A, Fanetti A C, Maspero S, Carone S, Mincuzzi A, Candela G, Scuderi T, Gentilini M A, Piffer S, Rosso S, Barchielli A, Caldarella A, Bianconi F, Stracci F, Contiero P, Tagliabue G, Rugge M, Zorzi M, Beggiato S, Brustolin A, Gatta G, Rugge M, De Angelis R, Zanetti R, Maurina A, Oniščuka M, Mousavi M, Lipunova N, Vincerževskienė I, Agius D, Calleja N, Siesling S, Visser O, Larønningen S, Møller B, Dyzmann-Sroka A, Trojanowski M, Góźdź S, Mierzwa T, Molong L, Rachtan J, Szewczyk S, Błaszczyk J, Kępska K, Kościańska B, Amunicka R, Ostrowski A, Zwierko M, Kaczmarek W, Maksimowicz K M, Purwin-Porowska E, Reca E, Wójcik-Tomaszewska J, Czajkowska E, Motnyk M, Grądalska-Lampart M, Radziszewska A U, Gos A, Talerczyk M, Wyborska M, Didkowska J A, Wojciechowska U, Bielska-Lasota M, Forjaz de Lacerda G, Rego R A, Carrito B, Pais A, Bento M J A T, Rodrigues J R, Mayer-da-Silva A, Miranda A, Blaga L M, Coza D, Valkov M Y, Gusenkova L, Lazarevich O, Prudnikova O, Vjushkov D M, Egorova A G, Orlov A E, Kudyakov L A, Pikalova L V, Adamcik J, Safaei Diba C, Primic-Žakelj M, Zadnik V, Gil L, Lopez de Munain A, Herrera A A, Rojas D, Chillarón R J, Navarro A I M, Marcos-Gragera R, Vilardell Gil M L, Molina E, Sánchez Perez M J, Franch Sureda P, Ramos Montserrat M, Chirlaque M D, Navarro C, Ardanaz E, Guevara M, Cañete-Nieto A, Peris-Bonet R, Carulla M, Galceran J, Almela F, Sabater C, Khan S, Pettersson D, Dickman P, Staehelin K, Struchen B, Egger Hayoz C, Bouchardy C, Schaffar R, Rössle M, Mousavi S M, Bulliard J L, Maspoli-Conconi M, Herrmann C, Kuehni C E, Redmond S M, Bordoni A, Ortelli L, Chiolero A, Konzelmann I, Matthes K L, Rohrmann S, Broggio J, Rashbass J, Fitzpatrick D, Gavin A, Clark D I, Deas A J, Huws D W, Allemani C, Coleman M P, Di Carlo V, Girardi F, Matz M, Minicozzi P, Montel L, Nikšić M, Ssenyonga N, Stephens R, Stiller C, Chalker E, Smith M, Walton R, You H, Qin Li S, Dugdale S, Moore J, Philpot S, Pfeiffer R, Thomas H, Stokes B C, Venn A, Farrugia H, Thursfield V, Dowling J, Currow D, Fowler C, Lewis C,
Affiliation:
1. Cancer Survival Group, London School of Hygiene and Tropical Medicine, London, UK 2. Cancer Division, University College London Hospitals NHS Foundation Trust, London, UK 3. National Cancer Registration and Analysis Service, Public Health England, London, UK 4. Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy 5. Danish Cancer Society, Copenhagen, Denmark 6. Registo Oncológico Regional do Norte, Porto, Portugal 7. Cancer Registry of St Gallen-Appenzell, St Gallen, Switzerland 8. Epidemiology Unit and Girona Cancer Registry, Girona, Spain 9. Registro Español de Tumores Infantiles, Valencia, Spain 10. Arkhangelsk Regional Cancer Registry, Arkhangelsk, Russian Federation 11. Centers for Disease Control and Prevention, Atlanta, Georgia, USA 12. British Columbia Cancer Registry, Vancouver, British Columbia, Canada 13. New South Wales Cancer Registry, Alexandria, Australia 14. Quito Cancer Registry, Quito, Ecuador 15. Ontario Cancer Registry, Toronto, Ontario, Canada 16. The Cancer Registry of Norway, Oslo, Norway 17. Registro de Câncer de Base Populacional de Aracaju, Aracaju, Brazil 18. State Health Registry of Iowa, Iowa City, Iowa, USA
Abstract
Abstract
Background
Global variations in survival for brain tumors are very wide when all histological types are considered together. Appraisal of international differences should be informed by the distribution of histology, but little is known beyond Europe and North America.
Methods
The source for the analysis was the CONCORD database, a program of global surveillance of cancer survival trends, which includes the tumor records of individual patients from more than 300 population-based cancer registries. We considered all patients aged 0-99 years who were diagnosed with a primary brain tumor during 2000-2014, whether malignant or nonmalignant. We presented the histology distribution of these tumors, for patients diagnosed during 2000-2004, 2005-2009, and 2010-2014.
Results
Records were submitted from 60 countries on 5 continents, 67 331 for children and 671 085 for adults. After exclusion of irrelevant morphology codes, the final study population comprised 60 783 children and 602 112 adults. Only 59 of 60 countries covered in CONCORD-3 were included because none of the Mexican records were eligible. We defined 12 histology groups for children, and 11 for adults. In children (0-14 years), the proportion of low-grade astrocytomas ranged between 6% and 50%. Medulloblastoma was the most common subtype in countries where low-grade astrocytoma was less commonly reported. In adults (15-99 years), the proportion of glioblastomas varied between 9% and 69%. International comparisons were made difficult by wide differences in the proportion of tumors with unspecified histology, which accounted for up to 52% of diagnoses in children and up to 65% in adults.
Conclusions
To our knowledge, this is the first account of the global histology distribution of brain tumors, in children and adults. Our findings provide insights into the practices and the quality of cancer registration worldwide.
Funder
Children with Cancer UK
Publisher
Oxford University Press (OUP)
Subject
Cancer Research,Neurology (clinical),Oncology
Cited by
18 articles.
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