Epidemiology of brainstem high-grade gliomas in children and adolescents in the United States, 2000-2017

Author:

Patil Nirav1ORCID,Kelly Michael E2,Yeboa Debra Nana3,Buerki Robin A4,Cioffi Gino15,Balaji Sweta6,Ostrom Quinn T17,Kruchko Carol1ORCID,Barnholtz-Sloan Jill S158

Affiliation:

1. Central Brain Tumor Registry of the United States, Hinsdale, Illinois

2. Department of Pediatrics, Northeast Ohio Medical University, Rootstown, Ohio

3. Department of Radiation Oncology at University of Texas, MD Anderson Cancer Center

4. Department of Neurology, University Hospitals, and Case Comprehensive Cancer Center, Cleveland, Ohio

5. The Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio

6. Hawken High School, Gates Mills, Ohio

7. Department of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas

8. Cleveland Center for Health Outcomes Research (CCHOR) Clevleand, Ohio

Abstract

Abstract Background Limited population-based data exist for the brainstem gliomas for children ages ≤19 years, which includes high-grade aggressively growing tumors such as diffuse intrinsic pontine glioma (DIPG). We examined the overall incidence and survival patterns in children with brainstem high-grade glioma (HGG) by age, sex, and race and ethnicity. Methods We used data from Central Brain Tumor Registry of the United States (CBTRUS), obtained through data use agreements with the Centers for Disease Control (CDC) and the National Cancer Institute (NCI) from 2000 to 2017, and survival data from the CDCs National Program of Cancer Registries (NPCR), from 2001 to 2016 for malignant brainstem HGG for ages ≤19 years (per WHO ICD-O-3 codes). HGG was determined by established histologic and/or imaging criteria. Age-adjusted incidence rates and survival data were used to assess differences overall and by age, sex race, and ethnicity. Results The incidence of brainstem HGG was higher among the female and Non-Hispanic population. Majority (69.8%) of these tumors were diagnosed radiographically. Incidence was higher in children aged 1-9 years compared to older children. Whites had a higher incidence compared to Blacks. However, the risk of death was higher among Blacks and Other race compared to Whites. There was no difference in survival by sex. Conclusions We report the most comprehensive incidence and survival data on these lethal brainstem HGGs. Incidence and survival among patients with brainstem HGGs differed significantly by race, ethnicity, age-groups, and grade.

Funder

Centers for Disease Control and Prevention

Cancer Prevention and Research Institute of Texas

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Neurology (clinical),Oncology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3