Affiliation:
1. School of Pharmacy, Nantong University , Nantong , China
2. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University , Shenyang , China
Abstract
Abstract
Objectives
The conducted search reveals that Juglans mandshurica Maximowicz, called Manchuria walnuts, had many local uses that can be categorized into cancer, dermatosis and acesodyne.
Key findings
Various metabolites including diarylheptanoids, naphthoquinones, and flavonoids (also their glycosides) were reported as bioactive metabolites. The isolated metabolites and extracts from J. mandshurica showed different biological activity including cytotoxicity, anti-inflammation, antimelanotic, anticomplement, anti-HIV, antimicrobial and anti-obesity activity.
Summary
It is indicated that this review will add value to more scientific research on J. mandshurica and enhance the increased interest in the sustainable commercialization of J. mandshurica. It also leads to the validation of unverified ethnobotanical claims. Future studies on J. mandshurica would be focused to establish the links between the pharmacological activity, bioactive metabolites, and traditional uses.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Jiangsu Province
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Reference67 articles.
1. The importance of weeds in ethnopharmacology;Stepp;J Ethnopharmacol,2001
2. Discovery and resupply of pharmacologically active plant-derived natural products: a review;Atanasov;Biotechnol Adv,2015
3. Ethnopharmacology, phytochemistry, and biological activities of Cymbopogon citratus (DC.) Stapf extracts;Ekpenyong;Chin J Nat Med,2015
4. Anti-parasite drugs sweep Nobel prize in medicine 2015;Callaway;Nature,2015
5. Arnica montana L. – a plant of healing: review;Kriplani;J Pharm Pharmacol,2017