Impact of intensification with raltegravir on HIV-1-infected individuals receiving monotherapy with boosted PIs

Author:

Puertas Maria C1,Gómez-Mora Elisabet1,Santos José R2,Moltó José2,Urrea Víctor1,Morón-López Sara1,Hernández-Rodríguez Agueda3,Marfil Silvia1,Martínez-Bonet Marta456,Matas Lurdes37,Muñoz-Fernández Mª Angeles456,Clotet Bonaventura128,Blanco Julià18,Martinez-Picado Javier189

Affiliation:

1. AIDS Research Institute IrsiCaixa, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Spain

2. ‘Lluita Contra la Sida’ Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, Spain

3. Servicio de Microbiologia, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain

4. Laboratory of Immuno Molecular Biology, Section of Immunology, Hospital General Universitario Gregorio Marañon, IiSGM, Madrid, Spain

5. Spanish HIV HGM BioBank, Madrid, Spain

6. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain

7. CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain

8. Universitat de Vic – Universitat Central de Catalunya (UVic-UCC), Vic, Spain

9. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain

Funder

MSD

FEDER

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology,Microbiology (medical)

Reference34 articles.

1. Combination antiretroviral therapy and the risk of myocardial infarction;Friis-Møller;N Engl J Med,2003

2. Changes in renal function associated with tenofovir disoproxil fumarate treatment, compared with nucleoside reverse-transcriptase inhibitor treatment;Gallant;Clin Infect Dis,2005

3. Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway;Brinkman;AIDS,1998

4. Tenofovir-associated renal and bone toxicity;Woodward;HIV Med,2009

5. Cost-effectiveness analysis of protease inhibitor monotherapy vs. ongoing triple-therapy in the long-term management of HIV patients;Oddershede;J Int AIDS Soc,2014

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