Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19-Reference-Cited by-同舟云学术

Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19

Published:2020-08-19 Issue:11 Volume:222 Page:1789-1793
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Guervilly Christophe¹²,Burtey Stephane³⁴^ORCID,Sabatier Florence⁴⁵⁶,Cauchois Raphaël⁴⁷,Lano Guillaume³⁴,Abdili Evelyne⁵,Daviet Florence³,Arnaud Laurent⁵,Brunet Philippe³⁴,Hraiech Sami¹²,Jourde-Chiche Noémie³⁴,Koubi Marie⁷,Lacroix Romaric⁴⁵,Pietri Léa⁸,Berda Yaël⁵,Robert Thomas³⁴,Degioanni Clara⁶,Velier Mélanie⁴⁵,Papazian Laurent¹²,Kaplanski Gilles⁴⁷,Dignat-George Françoise⁴⁵^ORCID

Affiliation:

1. Medical Intensive Care Unit, North Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France

2. Center for Studies and Research on Health Services and Quality of Life, Aix-Marseille University, Marseille, France

3. Department of Nephrology and Renal Transplantation, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France

4. Aix-Marseille University, INSERM 1263, INRAE, C2VN, Marseille, France

5. Laboratory of Hematology and Vascular Biology, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France

6. Cell Therapy Unit, INSERM CBT1409, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France

7. Department of Internal Medicine and Clinical Immunology, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France

8. Department of Nutrition, Metabolic Diseases, Endocrinology, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France

Abstract

Abstract Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CECs) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Together, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.

Funder

Aix-Marseille University

INSERM

Assistance Publique-Hôpitaux de Marseille

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiaa528/33778647/jiaa528.pdf

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