Hepatitis E Virus Seroprevalence is Associated with Neurodegenerative Disorders in Older People with Dementia: A Case-Control Study-Reference-Cited by-同舟云学术

Hepatitis E Virus Seroprevalence is Associated with Neurodegenerative Disorders in Older People with Dementia: A Case-Control Study

Published:2022-06-27 Issue:7 Volume:227 Page:873-877
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Pérez-García Felipe¹²³^ORCID,Vázquez-Morón Sonia¹,Burgueño-García Iván⁴,Muñoz-Gómez María José¹,Zea-Sevilla María Ascensión⁴,Calero Miguel⁴⁵⁶,Martínez Isidoro¹⁷^ORCID,Rábano Alberto⁴⁶,Resino Salvador¹⁷^ORCID

Affiliation:

1. Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III , Majadahonda , Spain

2. Servicio de Microbiología Clínica, Hospital Universitario Príncipe de Asturias , Madrid , Spain

3. Universidad de Alcalá, Facultad de Medicina, Departamento de Biomedicina y Biotecnología , Madrid , Spain

4. Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III , Madrid , Spain

5. Unidad Funcional Investigación de Enfermedades Crónicas, Instituto de Salud Carlos III , Majadahonda , Spain

6. Banco de Tejidos, Departamento de Neuropatología, Fundación Centro de Investigación en Enfermedades Neurológicas, Instituto de Salud Carlos III (FCIEN-ISCIII) , Madrid , Spain

7. Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid , Spain

Abstract

Abstract In this case-control study, we evaluated the association between serum antibodies against hepatitis E virus (HEV) and central nervous system (CNS) neurodegenerative disorders (NDs) in older people with dementia. The presence of anti-HEV antibodies was related to a higher adjusted odds ratio (aOR) of having CNS NDs by neuropathological diagnosis (aOR, 2.13; P = .007) and clinical/neuropathological diagnosis (1.84; P = .02). Besides, serum anti-HEV antibodies were directly related to neuropathological injury (higher vascular pathology [aOR, 1.97; P = .006]) and higher probability of Alzheimer-type pathology (1.84; P = .02). In conclusion, the presence of anti-HEV antibodies was related to higher odds of CNS NDs and neuropathological injury in older people.

Funder

Centro de Investigación Biomédica en Red

Agencia Estatal de Investigación

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiac268/45023030/jiac268.pdf

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