Zika Virus Changes Methylation of Genes Involved in Immune Response and Neural Development in Brazilian Babies Born With Congenital Microcephaly-Reference-Cited by-同舟云学术

Zika Virus Changes Methylation of Genes Involved in Immune Response and Neural Development in Brazilian Babies Born With Congenital Microcephaly

Published:2020-07-02 Issue:3 Volume:223 Page:435-440
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Anderson Denise¹^ORCID,Neri João I C F²,Souza Cássio R M²,Valverde Joanna G²,De Araújo Josélio M G²,Nascimento Maria D S B³,Branco Rebeca C C³,Arrais Nivia M R⁴,Lassmann Timo¹^ORCID,Blackwell Jenefer M¹,Jeronimo Selma M B²⁵

Affiliation:

1. Telethon Kids Institute, University of Western Australia, Perth Children’s Hospital, Perth, Western Australia, Australia

2. Institute of Tropical Medicine of Rio Grande do Norte, Department of Biochemistry, Universidade Federal do Rio Grande do Norte, Natal, Rio de Grande do Norte, Brazil

3. Department of Pathology, Federal University of Maranhão, São Luis, Maranhão, Brazil

4. Department of Pediatrics, Federal University of Rio Grande do Norte, Empresa Brasileira de Servicos Hospitalares, Natal, Rio de Grande do Norte, Brazil

5. National Institute of Science and Technology of Tropical Diseases, Natal, Rio de Grande do Norte, Brazil

Abstract

Abstract The recent increase in babies born with brain and eye malformations in Brazil is associated with Zika virus (ZIKV) infection in utero. ZIKV alters host DNA methylation in vitro. Using genome-wide DNA methylation profiling we compared 18 babies born with congenital ZIKV microcephaly with 20 controls. We found ZIKV-associated alteration of host methylation patterns, notably at RABGAP1L which is important in brain development, at viral host immunity genes MX1 and ISG15, and in an epigenetic module containing the causal microcephaly gene MCPH1. Our data support the hypothesis that clinical signs of congenital ZIKV are associated with changes in DNA methylation.

Funder

Wesfarmers

Coordination for the Improvement of Higher Education Personnel, Ministry of Education, Brazil

National Council for Scientific and Technological Development

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiaa383/33529590/jiaa383.pdf

Reference15 articles.

1. Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: an interrupted time series analysis;Paixão;PLoS Negl Trop Dis,2019