BNT162b2 mRNA COVID-19 Vaccine Effectiveness in the Prevention of SARS-CoV-2 Infection: A Preliminary Report

Author:

Bianchi Francesco Paolo1,Germinario Cinzia Annatea1,Migliore Giovanni2,Vimercati Luigi3,Martinelli Andrea1,Lobifaro Annamaria1,Tafuri Silvio1,Stefanizzi Pasquale1,Amoruso Fabio,Capodiferro Luca,De Crescenzio Irene,Furio Alessandro,Lattanzio Sabrina,Nozza Mirella,Parnoffi Nicole,Rella Michela,Riformato Giacomo,Spinelli Giuseppe,Manicone Annalucia,

Affiliation:

1. Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Bari, Italy

2. Bari Policlinico General Hospital, Bari, Italy

3. Department of Interdisciplinary Medicine, Aldo Moro University of Bari, Bari, Italy

Abstract

Abstract In the preregistration trial, data on efficacy of BNT162b2 mRNA vaccine against SARS-CoV-2 infection were not collected. This study aimed to evaluate vaccine effectiveness (VE) against documented infection. Bari Policlinico University Hospital health care workers (HCWs) who completed the vaccination schedule were matched with HCWs who had refused vaccination. VE for documented infection was 61.9% (95% confidence interval [CI], 19.2%–82.0%) 14–20 days after first dose, 87.9% (95% CI, 51.7%–97.0%) 21–27 days after first dose, and 96.0% (95% CI, 82.2%–99.1%) 7 or more days after second dose. Unvaccinated HCWs remain a concern in the context of the pandemic emergency.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Reference15 articles.

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