Unique Profile of Inflammation and Immune Activation in Pregnant People With HIV in the United States
Author:
Shiau Stephanie1ORCID, Jacobson Denise L2, Huo Yanling2, Kacanek Deborah2, Yee Lynn M3, Williams David B4, Haddad Lisa B5, Serghides Lena6, Powis Kathleen78, Sperling Rhoda S9, Williams Paige L10, Jao Jennifer11, Chadwick Ellen, Sanders Margaret Ann, Malee Kathleen, Paul Mary, Eser-Jose Ruth, McMullen-Jackson Chivon, Harris Lynnette, Purswani Murli, Baig Mahoobullah Mirza, Villegas Alma, Alvarado Marvin, Robinson Lisa-Gaye, Cooley Jawara Dia, Blood James, Garvie Patricia, Borkowsky William, Deygoo Nagamah Sandra, Lewis Jennifer, Dieudonne Arry, Bettica Linda, Johnson Juliette, Surowiec Karen, Knapp Katherine, Russell-Bell Jamie, Wilkins Megan, Love Stephanie, Rosario Nicolas, Angeli-Nieves Lourdes, Olivera Vivian, Kohlhoff Stephan, Dennie Ava, Kaye Jean, Wallier Jenny, Craig Karen, Silio Margarita, Sirois Patricia, Hutto Cecelia, Hickman Paige, Huldtquist Julie, Marullo Dan, Spector Stephen A, Figueroa Veronica, Loughran Megan, Nichols Sharon, McFarland Elizabeth, Kwon Christine, Glenny Carrie, Englund Jennifer, Rathore Mobeen, Mahmoudi Saniyyah, El-Hassan Sarah, Tejan Jamilah, Hayani Karen, Richardson Lourdes, Smith Renee, Miller Alina, Scott Gwendolyn, Garcia Gustavo Gil, Fernandez Gabriel, Cuadra Anai, Frederick Toni, Davtyan Mariam, Morales-Avendano Guadalupe, Rodriguez Zoe M, Torres Lizmarie, Scalley Nydia,
Affiliation:
1. Department of Biostatistics and Epidemiology, Rutgers School of Public Health , Piscataway, New Jersey , USA 2. Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health , Boston, Massachusetts , USA 3. Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine , Chicago, Illinois , USA 4. Ann and Robert H. Lurie Children's Hospital of Chicago , Chicago, Illinois , USA 5. Center for Biomedical Research, Population Council , New York, New York , USA 6. University Health Network and Department of Immunology and Institute of Medical Sciences, University of Toronto , Toronto , Canada 7. Departments of Internal Medicine and Pediatrics, Massachusetts General Hospital , Boston, Massachusetts , USA 8. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health , Boston, Massachusetts , USA 9. Department of Obstetrics, Gynecology, and Reproductive Health, Icahn School of Medicine at Mount Sinai , New York, New York , USA 10. Departments of Biostatistics and Epidemiology, Harvard T.H. Chan School of Public Health , Boston, Massachusetts , USA 11. Department of Pediatrics, Department of Medicine, Northwestern University Feinberg School of Medicine , Chicago, Illinois , USA
Abstract
Abstract
Background
Little is known about inflammation/immune activation during pregnancy in people with HIV (PWH) and growth in their children who are HIV-exposed and uninfected (CHEU).
Methods
Using data from the Pediatric HIV/AIDS Cohort Study and an HIV-seronegative comparison group, we assessed associations of (1) HIV status, mode of HIV acquisition (perinatally vs nonperinatally acquired), and type of antiretroviral therapy (ART) with inflammation/immune activation in pregnancy; and (2) inflammation/immune activation in pregnancy with growth of CHEU at 12 months. Interleukin 6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), soluble(s) TNF-α receptor 1 and 2 (sTNFR1, sTNFR2), sCD14, and sCD163 were measured between 13 and 27 weeks' gestation. Linear regression models were fit to estimate differences between groups for each log-transformed biomarker, adjusted for confounders.
Results
Pregnant PWH (188 total, 39 perinatally acquired, 149 nonperinatally acquired) and 76 HIV-seronegative persons were included. PWH had higher IL-6, sTNFR1, sCD14, and sCD163 and lower sTNFR2 compared to HIV-seronegative persons in adjusted models. Among PWH, sCD163 was higher in those with perinatally versus nonperinatally acquired HIV and on PI-based versus INSTI-based ART. Higher maternal concentrations of IL-6, sTNFR2, and hs-CRP were associated with poorer growth at 12 months.
Conclusions
Maternal HIV status is associated with a distinct profile of inflammation/immune activation during pregnancy, which may influence child growth.
Funder
Eunice Kennedy Shriver National Institute of Child Health and Human Development Office of the Director National Institutes of Health National Institute of Dental and Craniofacial Research National Institute of Allergy and Infectious Diseases National Institute of Neurological Disorders and Stroke National Institute on Deafness and Other Communication Disorders National Institute of Mental Health National Institute on Drug Abuse National Cancer Institute National Institute on Alcohol Abuse and Alcoholism National Heart, Lung, and Blood Institute Harvard T.H. Chan School of Public Health Tulane University School of Medicine NICHD Thrasher Research Fund
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Immunology and Allergy
Cited by
2 articles.
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