Detailed Transmission Network Analysis of a Large Opiate-Driven Outbreak of HIV Infection in the United States

Author:

Campbell Ellsworth M1,Jia Hongwei1,Shankar Anupama1,Hanson Debra1,Luo Wei1,Masciotra Silvina1,Owen S Michele1,Oster Alexandra M1,Galang Romeo R1,Spiller Michael W1ORCID,Blosser Sara J2,Chapman Erika2,Roseberry Jeremy C2,Gentry Jessica2,Pontones Pamela2,Duwve Joan23,Peyrani Paula4,Kagan Ron M5,Whitcomb Jeannette M6,Peters Philip J1,Heneine Walid1,Brooks John T1,Switzer William M1

Affiliation:

1. Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia

2. Indiana State Department of Health, Indianapolis

3. Indiana University Richard M. Fairbanks School of Public Health, Indianapolis

4. Division of Infectious Diseases, University of Louisville, Kentucky

5. Quest Diagnostics, Madison, New Jersey

6. LabCorp, Burlington, North Carolina

Abstract

We demonstrate that integration of laboratory, phylogenetic, and epidemiologic data sources allow detailed reconstruction of an outbreak. High-resolution reconstruction of outbreak phylodynamics allows prevention and intervention strategies to be tailored to community needs.

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

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