Progressive and Parallel Decline of Humoral and T-Cell Immunity in Convalescent Healthcare Workers with Asymptomatic or Mild-to-Moderate Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Author:

Casado Jose L1ORCID,Vizcarra Pilar1ORCID,Velasco Hector2,Hammerle Johannes3,McGee Amaranta4,Fernandez-Escribano Marina3,Vallejo Alejandro12

Affiliation:

1. Department of Infectious Diseases, Ramon y Cajal Hospital, Madrid, Spain

2. Laboratory of Immunovirology, Ramón y Cajal Hospital, Madrid, Spain

3. Department of Prevention of Occupational Risks, Ramón y Cajal Hospital, Madrid, Spain

4. Department of Preventive Medicine and Public Health, Ramón y Cajal Hospital, Madrid, Spain

Abstract

Abstract We investigated the duration of humoral and T-cell immune response in paired samples among 22 convalescent healthcare workers (HCWs). A median of 1.8 months after diagnosis, T-cell response was significantly lower in HCWs with early loss of antibodies (6 cases [27%]). After 5.1 months, antibody decline was observed in 77% of cases (41% seroreverted; P < .01), and 36% had lost T-cell response (75% lost response to spike protein). Persistence of immune response was observed in those who developed a greater adaptive immune response. Our data point to the initial immune response as the relevant player in coronavirus disease 2019 duration of protection.

Funder

Instituto de Salud Carlos III

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Reference15 articles.

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