Viral Load Dynamics in Plasma and Semen When Antiretroviral Therapy Is Initiated During Early HIV-1 Infection-Reference-Cited by-同舟云学术

Viral Load Dynamics in Plasma and Semen When Antiretroviral Therapy Is Initiated During Early HIV-1 Infection

Published:2023-11-24 Issue: Volume: Page:
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Gilada Trupti¹,Ulrich Angela K²³,Wang Yixin⁴,Lama Javier R⁵,Alfaro Ricardo⁶,Harb Socorro⁷,Daza Glenda⁷,Holte Sarah⁸⁹¹⁰^ORCID,Pasalar Siavash⁴^ORCID,Rios Jessica¹¹,Ganoza Carmela¹²,Dasgupta Sayan⁴^ORCID,Coombs Robert W⁷,Duerr Ann⁴⁸⁹

Affiliation:

1. Unison Medicare and Research Center , Mumbai , India

2. Center for Infectious Disease Research and Policy, University of Minnesota , Minneapolis, Minnesota , USA

3. Division of Environmental Health Science, University of Minnesota , Minneapolis, Minnesota , USA

4. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center , Seattle, Washington , USA

5. Asociación Civil Impacta Salud y Educación , Lima , Peru

6. Centro de Investigaciones Tecnológicas Biomédicas y Medioambientales , Lima , Peru

7. School of Medicine, University of Washington , Seattle, Washington , USA

8. Public Health Sciences Division, Fred Hutchinson Cancer Center , Seattle, Washington , USA

9. Department of Global Health, University of Washington , Seattle, Washington , USA

10. Department of Biostatistics, University of Washington , Seattle, Washington , USA

11. Pharmaceutical Product Development, Inc , Lima , Peru

12. HIV Vaccine Trials Network , Lima , Peru

Abstract

Abstract We assessed human immunodeficiency virus (HIV) load in plasma and semen during primary HIV infection using serial samples of semen and plasma during the first 24 weeks after diagnosis in untreated participants and those who started antiretroviral therapy (ART) immediately at diagnosis. In the absence of treatment, semen viral load was >1000 copies/mL in almost all specimens (83%) collected 2–10 weeks after the estimated date of HIV acquisition and remained >1000 copies/mL in 35% of untreated participants at the last observed time point. Thus, in the absence of ART, semen viral load remained at a level consistent with transmissibility throughout primary infection.

Funder

National Institute on Drug Abuse

US National Institutes of Health

International AIDS Society

National Agency for Research on AIDS

and Viral Hepatitis

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiad520/54338839/jiad520.pdf

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