Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19
Author:
Strunz Benedikt1ORCID, Maucourant Christopher1, Mehta Adi2, Wan Hui3, Du Likun3, Sun Dan1, Chen Puran1, Nordlander Anna4, Gao Yu1, Cornillet Martin1, Bister Jonna1, Kvedaraite Egle15, Christ Wanda1, Klingström Jonas1, Geanon Daniel1, Parke Åsa67, Ekwall-Larson Anna8, Rivino Laura910, MacAry Paul A11, Aleman Soo712, Buggert Marcus1, Ljunggren Hans-Gustaf1, Pan-Hammarström Qiang3, Lund-Johansen Fridtjof2, Strålin Kristoffer67, Björkström Niklas K1ORCID, , Sönnerborg Anders, Dillner Lena, Glans Hedvig, Nauclér Pontus, Rooyackers Olav, Mårtensson Johan, Eriksson Lars I, Persson Björn P, Grip Jonathan, Unge Christian, Djärv Therese, Religa Dorota, Sandberg John Tyler, Bergsten Helena, Brighenti Susanna, Butrym Marta, Chambers Benedict J, Cuapio Angelica, Lozano Isabel Diaz, Dzidic Majda, Emgård Johanna, Flodström-Tullberg Malin, Gorin Jean-Baptiste, Haroun-Izquierdo Alvaro, Hertwig Laura, Kalsum Sadaf, Kokkinou Efthymia, Marquardt Nicole, Lourda Magdalini, Maleki Kimia T, Malmberg Karl-Johan, Michaëlsson Jakob, Mjösberg Jenny, Moll Kirsten, Muvva Jagadeeswara Rao, Norrby-Teglund Anna, Medina Laura M Palma, Parrot Tiphaine, Radler Lena, Ringqvist Emma, Sandberg Johan K, Sekine Takuya, Soini Tea, Svensson Mattias, Tynell Janne, von Kries Andreas, Wullimann David, Perez-Potti André, Rivera-Ballesteros Olga, Varnaite Renata, Akber Mira, Berglin Lena, Brownlie Demi, Loreti Marco Giulio, Sohlberg Ebba, Kammann Tobias, Henriksson Elisabeth, Hammer Quirin
Affiliation:
1. Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital , Stockholm , Sweden 2. Department of Immunology, Oslo University Hospital , Oslo , Norway 3. Department of Biosciences and Nutrition, Karolinska Institutet , Stockholm , Sweden 4. Department of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge , Stockholm , Sweden 5. Department of Pathology and Cancer Diagnostics, Karolinska University Hospital , Stockholm , Sweden 6. Department of Medicine Huddinge, Karolinska Institutet , Stockholm , Sweden 7. Department of Infectious Diseases, Karolinska University Hospital , Stockholm , Sweden 8. Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet , Stockholm , Sweden 9. Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School , Singapore , Singapore 10. School of Cellular and Molecular Medicine, University of Bristol , Bristol , United Kingdom 11. Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore , Singapore , Singapore 12. Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet , Stockholm , Sweden
Abstract
Abstract
Background
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to severe disease with increased morbidity and mortality among certain risk groups. The presence of autoantibodies against type I interferons (aIFN-Abs) is one mechanism that contributes to severe coronavirus disease 2019 (COVID-19).
Methods
This study aimed to investigate the presence of aIFN-Abs in relation to the soluble proteome, circulating immune cell numbers, and cellular phenotypes, as well as development of adaptive immunity.
Results
aIFN-Abs were more prevalent in critical compared to severe COVID-19 but largely absent in the other viral and bacterial infections studied here. The antibody and T-cell response to SARS-CoV-2 remained largely unaffected by the presence aIFN-Abs. Similarly, the inflammatory response in COVID-19 was comparable in individuals with and without aIFN-Abs. Instead, presence of aIFN-Abs had an impact on cellular immune system composition and skewing of cellular immune pathways.
Conclusions
Our data suggest that aIFN-Abs do not significantly influence development of adaptive immunity but covary with alterations in immune cell numbers.
Funder
European Research Council European Union Horizon 2020 Swedish Research Council Swedish Cancer Society Swedish Society for Medical Research Swedish Foundation for Strategic Research Knut and Alice Wallenberg Foundation Novo Nordisk Foundation Karolinska Institutet Norwegian Health Authorities Oslo University Hospital Nordstjernan Region Stockholm
Publisher
Oxford University Press (OUP)
Cited by
1 articles.
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