Genetic Diversity of Cryptosporidium hominis in a Bangladeshi Community as Revealed by Whole-Genome Sequencing-Reference-Cited by-同舟云学术

Genetic Diversity of Cryptosporidium hominis in a Bangladeshi Community as Revealed by Whole-Genome Sequencing

Published:2018-03-05 Issue:2 Volume:218 Page:259-264
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Gilchrist Carol A¹,Cotton James A²,Burkey Cecelia¹,Arju Tuhinur³,Gilmartin Allissia¹,Lin Ye⁴,Ahmed Emtiaz³,Steiner Kevin¹,Alam Masud³,Ahmed Shahnawaz³,Robinson Guy⁵⁶,Zaman Sultan Uz³,Kabir Mamun³^ORCID,Sanders Mandy²,Chalmers Rachel M⁵⁶,Ahmed Tahmeed³,Ma Jennie Z⁷,Haque Rashidul³,Faruque Abu S G³,Berriman Matthew²,Petri William A¹

Affiliation:

1. Department of Medicine, University of Virginia, Charlottesville

2. Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

3. International Centre for Diarrhoeal Disease Research, Bangladesh

4. Department of Statistics, University of Virginia, Charlottesville

5. Cryptosporidium Reference Unit, Public Health Wales Microbiology, Singleton Hospital

6. Swansea University Medical School, Singleton Park, Swansea, United Kingdom

7. Department of Public Health Sciences, University of Virginia, Charlottesville

Abstract

In the developing world, Cryptosporidium is one of the top causes of infant diarrhea. In a Bangladesh community we have discovered that a substantial amount of genetic recombination and genetic polymorphism in surface proteins occurs in the Cryptosporidium hominis parasite.

Funder

National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

Wellcome Trust

Wellcome Trust Sanger Institute

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/article-pdf/218/2/259/25068491/jiy121.pdf