Long-term Memory Response After a Single Intramuscular Rabies Booster Vaccination 10–24 Years After Primary Immunization

Author:

De Pijper Cornelis A1ORCID,Langedijk Annefleur C1,Terryn Sanne2,Van Gucht Steven2,Grobusch Martin P1,Goorhuis Abraham1,Stijnis Cornelis1

Affiliation:

1. Amsterdam University Medical Centers, University of Amsterdam, Division of Internal Medicine, Department of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Amsterdam Infection and Immunity, Amsterdam Public Health, Amsterdam, Netherlands

2. National Reference Center of Rabies, Viral Diseases, Infectious Diseases in Humans, Sciensano, Brussels, Belgium

Abstract

Abstract Background Published data regarding long-lasting immunological rabies memory after pre-exposure prophylaxis (PrEP) are scarce. We tested the hypothesis that rabies booster immunization elicits rapid anamnestic responses. Methods For this observational study, we included participants who had received PrEP 10–24 years before inclusion. We measured rabies antibody titers before, and on days 3, 7, and 14 after a single intramuscular booster. Results All 28 participants responded adequately regardless of route of administration or 2-dose vs 3-dose PrEP regimen. Conclusion Rabies immunological memory is reactivated within 7 days after a single intramuscular booster immunization, even when administered 10–24 years after PrEP.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Reference15 articles.

1. Rabies vaccines: WHO position paper, April 2018—recommendations;World Health Organization;Vaccine,2018

2. Rabies;Fooks;Nat Rev Dis Primers,2017

3. Memory B cells;Kurosaki;Nat Rev Immunol,2015

4. The cellular immune response to rabies vaccination: a systematic review;Overduin;Vaccines (Basel),2019

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