COVID-19 Vaccines: Should We Fear ADE?-Reference-Cited by-同舟云学术

COVID-19 Vaccines: Should We Fear ADE?

Published:2020-08-12 Issue:12 Volume:222 Page:1946-1950
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Halstead Scott B¹,Katzelnick Leah²³

Affiliation:

1. Independent Consultant, University of California Berkeley, Berkeley, California, USA

2. Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, California, USA

3. Department of Biology, University of Florida, Gainesville, Florida, USA

Abstract

Abstract Might COVID-19 vaccines sensitize humans to antibody-dependent enhanced (ADE) breakthrough infections? This is unlikely because coronavirus diseases in humans lack the clinical, epidemiological, biological, or pathological attributes of ADE disease exemplified by dengue viruses (DENV). In contrast to DENV, SARS and MERS CoVs predominantly infect respiratory epithelium, not macrophages. Severe disease centers on older persons with preexisting conditions and not infants or individuals with previous coronavirus infections. Live virus challenge of animals given SARS or MERS vaccines resulted in vaccine hypersensitivity reactions (VAH), similar to those in humans given inactivated measles or respiratory syncytial virus vaccines. Safe and effective COVID-19 vaccines must avoid VAH.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiaa518/33921695/jiaa518.pdf

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