Patterns of Antibody Response to Severe Acute Respiratory Syndrome Coronavirus 2 Among 1.6 Million Blood Donors: Impact of Vaccination, United States, December 2020

Patterns of Antibody Response to Severe Acute Respiratory Syndrome Coronavirus 2 Among 1.6 Million Blood Donors: Impact of Vaccination, United States, December 2020–June 2021

Published:2021-10-09 Issue:1 Volume:225 Page:5-9
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Dodd Roger Y¹^ORCID,Notari Edward P¹,Brodsky Jaye P²,Foster Gregory A¹,Xu Meng¹,Saá Paula¹,Stramer Susan L¹

Affiliation:

1. American Red Cross, Scientific Affairs, Gaithersburg, Maryland, USA

2. Quality Analytics, Deerfield, Illinois, USA

Abstract

Abstract From December 2020 to June 2021, 1654487 blood donors were tested for antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S1 protein, and 1028547 (62.17%) were reactive. A rapid increase in prevalence was due to vaccination. Among a subset of 1567446 donors, 729771 (46.56%) reported SARS-CoV-2 vaccination, of whom 633769 (86.84%) were S1-antibody reactive only in response to vaccination and 68269 (9.35%) were reactive to both S1 and nucleocapsid in response to prior infection; the remainder were not reactive to either antibody. Among the 837675 (53.44%) donors who did not report vaccination, 210022 (25.07%) had reactivity to both antibodies and 29446 (3.52%) to S1 only.

Funder

Centers for Disease Control and Prevention

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiab514/40541449/jiab514.pdf

Reference10 articles.

1. Change in donor characteristics and antibodies to SARS-CoV-2 in donated blood in the US, June–August 2020.;Dodd;JAMA,2020

2. Estimated US infection and vaccine-induced SARS-CoV-2 seroprevalence based on blood donations, July 2020–May 2021 [manuscript published online ahead of print 2 September 2021].;Jones;JAMA,2021

3. Use of US blood donors for national serosurveillance of SARS-CoV-2 antibodies: basis for an expanded national serosurveillance program [manuscript published online ahead of print 10 June 2021].;Stone;Clin Infect Dis,2021