T-Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of Coronavirus Disease 2019-Reference-Cited by-同舟云学术

T-Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of Coronavirus Disease 2019

Published:2020-05-07 Issue:2 Volume:222 Page:198-202
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Jiang Mei¹,Guo Yang¹,Luo Qing¹,Huang ZiKun¹,Zhao Rui¹,Liu ShuYuan¹,Le AiPing²,Li JunMing¹,Wan LaGen¹

Affiliation:

1. Department of Clinical Laboratory, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

2. Department of Transfusion, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

Abstract

Abstract This study evaluated the significance of lymphocyte subset detection in peripheral blood in the diagnosis and prognosis of coronavirus disease 2019 (COVID-19). Our results revealed that CD3+ T cells, CD4+ T cells, CD8+ T cells, and natural killer cells were significantly decreased in patients with COVID-19. These patients had a relatively slight decrease in CD4+ T cells but a severe decrease in CD8+ T cells. The significantly elevated CD4/CD8 ratio was observed in COVID-19 patients. T-cell subset counts were related to the severity and prognosis of COVID-19, suggesting that the counts of CD8+ T and CD4+ T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity.

Funder

Applied Research Training Program

Science and Technology Plan Project

Jiangxi Provincial Health Planning Commission

Education Department of Jiangxi Province

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiaa252/33183242/jiaa252.pdf

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