A Pan-Ebolavirus Monoclonal Antibody Cocktail Provides Protection Against Ebola and Sudan Viruses

Author:

Liu Guodong1,He Shihua1,Chan Michael1,Zhang Zirui12,Schulz Helene1,Cao Wenguang1,Rahim Md Niaz12,Audet Jonathan1,Garnett Lauren12,Wec Anna3,Chandran Kartik3,Qiu Xiangguo1,Banadyga Logan12ORCID

Affiliation:

1. Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada

2. Department of Medical Microbiology and Infectious Diseases, University of Manitoba , Winnipeg, Manitoba , Canada

3. Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, New York

Abstract

Abstract Filoviruses, including ebolaviruses and marburgviruses, can cause severe and often fatal disease in humans. Over the past several years, antibody therapy has emerged as a promising strategy for the treatment of filovirus disease. Here, we describe 2 distinct cross-reactive monoclonal antibodies (mAbs) isolated from mice immunized with recombinant vesicular stomatitis virus–based filovirus vaccines. Both mAbs recognized the glycoproteins of multiple different ebolaviruses and exhibited broad but differential in vitro neutralization activities against these viruses. By themselves, each mAb provided partial to full protection against Ebola virus in mice, and in combination, the mAbs provided 100% protection against Sudan virus challenge in guinea pigs. This study identified novel mAbs that were elicited through immunization and able to provide protection from ebolavirus infection, thus enriching the pool of candidate therapeutics for treating Ebola disease.

Funder

Public Health Agency of Canada

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Reference30 articles.

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