Levels of Angiopoietin 2 Are Predictive for Mortality in Patients Infected With Yellow Fever Virus-Reference-Cited by-同舟云学术

Levels of Angiopoietin 2 Are Predictive for Mortality in Patients Infected With Yellow Fever Virus

Published:2023-09-15 Issue: Volume: Page:
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

van de Weg Cornelia A M¹²,Thomazella Mateus V¹^ORCID,Marmorato Mariana P¹,Correia Carolina A¹,Dias Juliana Z C¹,Maestri Alvino¹,Zanella Luiz G F A B E¹,Cerqueira Natalia B³,Félix Alvina C⁴,Moreira Carlos H V⁵⁶⁷⁸,Buccheri Renata⁵,Costa Priscilla R¹,Kallás Esper G¹⁶

Affiliation:

1. Medical Investigation Laboratory 60, School of Medicine, University of São Paulo , Brazil

2. Department of Internal Medicine, Erasmus Medical Center , Rotterdam , the Netherlands

3. School of Medicine, Hospital das Clínicas, Sã‌o Paulo, Brazil

4. Institute of Tropical Medicine, University of São Paulo , São Paulo, Brazil‌

5. Infectious Diseases Institute “Emílio Ribas” , São Paulo, Brazil‌

6. Department of Infectious and Parasitic Diseases, School of Medicine, University of São Paulo , Brazil

7. Department of HIV, Infectious Diseases and Global Medicine, University of California , San Francisco

8. Zuckerberg San Francisco General Hospital , California

Abstract

Abstract In 2018 there was a large yellow fever outbreak in São Paulo, Brazil, with a high fatality rate. Yellow fever virus can cause, among other symptoms, hemorrhage and disseminated intravascular coagulation, indicating a role for endothelial cells in disease pathogenesis. Here, we conducted a case-control study and measured markers related to endothelial damage in plasma and its association with mortality. We found that angiopoietin 2 is strongly associated with a fatal outcome and could serve as a predictive marker for mortality. This could be used to monitor severe cases and provide care to improve disease outcome.

Funder

São Paulo Research Foundation

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiad389/51791853/jiad389.pdf

Reference15 articles.

1. Yellow fever: an update;Monath;Lancet Infect Dis,2001

2. Predictors of mortality in patients with yellow fever: an observational cohort study;Kallas;Lancet Infect Dis,2019

3. Consumptive coagulopathy of severe yellow fever occurs independently of hepatocellular tropism and massive hepatic injury;Bailey;Proc Natl Acad Sci U S A,2020

4. Serum angiopoietin-2 and soluble VEGF receptor 2 are surrogate markers for plasma leakage in patients with acute dengue virus infection;van de Weg;J Clin Virol,2014

5. Reconsideration of histopathology and ultrastructural aspects of the human liver in yellow fever;Quaresma;Acta Trop,2005

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Systems Immunology Approaches to Understanding Immune Responses in Acute Infection of Yellow Fever Patients;2024-05-07

2. A Review on The Pathogenesis of Cardiovascular Disease of Flaviviridea Viruses Infection;Viruses;2024-02-27