Distinct Inflammatory Phenotypes Are Associated With Subclinical and Clinical Cardiovascular Disease in People With Human Immunodeficiency Virus
Author:
McGettrick Padraig12, Tinago Willard1, O’Brien Julie3, Miles Sarah1, Lawler Leo4, Garcia-Leon Alejandro1, Mahon Niall5, Lambert John2, Sheehan Gerard2, Landay Alan6, Sabin Caroline A7, Cotter Aoife G2, Mallon Patrick W G18, , McGettrick P, Alvarez Barco E, Tinago W, Garcia-Leon A, McDermott A, McGinty T, Cotter A G, Macken A, Mallon P W G, Kavanagh E, McCarthy G, Sheehan G, Lambert J, Powderly W, Compston J, Sabin C, Cotter A, Muldoon E, Sheehan G, McGinty T, Lambert J S, Green S, Leamy K, Kenny G, McCann K, McCann R, O’Broin C, Waqas S, Savinelli S, Feeney E, Mallon P W G, Garcia Leon A, Miles S, Alalwan D, Negi R, de Barra E, McConkey S, Hurley K, Sulaiman I, Horgan M, Sadlier C, Eustace J, Kelly C, Bracken T, Whelan B, Low J, Yousif O, McNicholas B, Courtney G, Gavin P
Affiliation:
1. Centre for Experimental Pathogen Host Research, University College Dublin , Dublin , Ireland 2. Department of Infectious Diseases, Mater Misericordiae University Hospital , Dublin , Ireland 3. Department of Radiology, University Hospital Limerick, Limerick, Ireland 4. Department of Radiology, Mater Misericordiae University Hospital , Dublin , Ireland 5. Department of Cardiology, Mater Misericordiae University Hospital , Dublin , Ireland 6. Department of Internal Medicine, Rush University Medical Center , Chicago, Illinois , United States of America 7. Institute for Global Health, University College London , London , United Kingdom 8. Department of Infectious Diseases, St Vincent’s University Hospital , Dublin , Ireland
Abstract
Abstract
Despite inflammation being implicated in cardiovascular disease (CVD) in people with human immunodeficiency virus (PWH), considerable heterogeneity within populations of PWH exists. Stratifying CVD risk based on inflammatory phenotype could play an important role. Using principal component analyses and unsupervised hierarchical clustering, we examined 38 biomarkers to identify inflammatory phenotypes in 2 independent cohorts of PWH. We identified 3 distinct inflammatory clusters present in both cohorts that were associated with altered risk of both subclinical CVD (cohort 1) and prevalent clinical CVD (cohort 2) after adjusting for CVD risk factors. These data support precision medicine approaches to enhance CVD risk assessment in PWH.
Funder
Irish Health Research Board
Publisher
Oxford University Press (OUP)
Cited by
1 articles.
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