Association of Endothelial Protein C Receptor (EPCR) rs867186 Gene Polymorphism With Increased Levels of Soluble EPCR and High Risk of Severe Malaria and Fatality in Beninese Children-Reference-Cited by-同舟云学术

Association of Endothelial Protein C Receptor (EPCR) rs867186 Gene Polymorphism With Increased Levels of Soluble EPCR and High Risk of Severe Malaria and Fatality in Beninese Children

Published:2022-11-23 Issue:2 Volume:227 Page:179-182
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Blankson Samuel Odarkwei¹²,Dikroh Liliane³,Tettey Patrick³,Tornyigah Bernard¹³,Adamou Rafiou¹⁴,Moussiliou Azizath¹⁴,Alao Maroufou J⁵,Amoussou Annick⁶,Padounou Caroline⁷,Milet Jacqueline¹,Mensah Benedicta Ayiedu³,Aniweh Yaw²,Ndam Nicaise Tuikue¹²,Roussilhon Christian⁸,Tahar Rachida¹²^ORCID

Affiliation:

1. Université de Paris Cité, MERIT, IRD, Paris , France

2. West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana , Accra , Ghana

3. Department of Immunology and Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana , Accra , Ghana

4. Institut de Recherche Clinique du Benin , Calavi , Benin

5. Département de Pédiatrie, Centre Hospitalier Universitaire de La Mère et De L'Enfant Lagune , Cotonou , Benin

6. Service de Pédiatrie, Centre Hospitalo-Universitaire, Suruléré , Cotonou , Benin

7. Centre Hospitalier Universitaire de l’Oueme/Plateau , Porto-Novo , Benin

8. Département Génomes et Génétique, Institut Pasteur , Paris , France

Abstract

Abstract The endothelial protein C receptor (EPCR)–rs867186 G allele has been linked to high plasma levels of soluble EPCR (sEPCR) and controversially associated with either susceptibility or resistance to severe and cerebral malaria. In this study, quantitative enzyme-linked immunosorbent assay and sequencing were used to assess sEPCR levels and EPCR-rs867186 polymorphism in blood samples from Beninese children with different clinical presentations of malaria. Our findings show that sEPCR levels were higher at hospital admission than during convalescence and that EPCR-rs867186 G allele was associated with increased sEPCR plasma levels, malaria severity, and mortality rate (P < .001, P = .03, and P = .04, respectively), suggesting a role of sEPCR in the pathogenesis of severe malaria.

Funder

Institut de Recherche pour le Dévelopement,

Danish International Development Agency

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiac461/47887900/jiac461.pdf

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