Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs From Ebola Virus Disease-Reference-Cited by-同舟云学术

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Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs From Ebola Virus Disease

Published:2017-12-21 Issue:3 Volume:217 Page:451-455
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Meyer Michelle¹,Huang Eric²,Yuzhakov Olga³,Ramanathan Palaniappan¹,Ciaramella Giuseppe³,Bukreyev Alexander¹⁴⁵⁶

Affiliation:

1. Department of Pathology, University of Texas Medical Branch, Galveston, Texas

2. Moderna Therapeutics, Cambridge, Massachusetts

3. Valera LLC, Cambridge, Massachusetts

4. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas

5. Galveston National Laboratory, University of Texas Medical Branch, Galveston, Texas

6. Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/article-pdf/217/3/451/24263154/jix592.pdf

Reference15 articles.

1. Phase 2 placebo-controlled trial of two vaccines to prevent Ebola in liberia;Kennedy;N Engl J Med,2017

2. The effect of dose on the safety and immunogenicity of the VSV Ebola candidate vaccine: a randomised double-blind, placebo-controlled phase 1/2 trial;Huttner;Lancet Infect Dis,2015

3. Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose;Chahal;Proc Natl Acad Sci U S A,2016

4. Safety and immunogenicity of DNA vaccines encoding Ebolavirus and Marburgvirus wild-type glycoproteins in a phase I clinical trial;Sarwar;J Infect Dis,2015

5. Direct gene transfer into mouse muscle in vivo;Wolff;Science,1990

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