RTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated <i>Plasmodium falciparum</i> Circumsporozoite Proteins-Reference-Cited by-同舟云学术

RTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated Plasmodium falciparum Circumsporozoite Proteins

Published:2023-10-27 Issue: Volume: Page:
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Jairoce Chenjerai¹²,Macià Dídac¹³,Torres-Yaguana Jorge P¹,Mayer Leonie¹⁴,Vidal Marta¹,Santano Rebeca¹,Hurtado-Guerrero Ramón⁵⁶⁷,Reiter Karine⁸,Narum David L⁸,Lopez-Gutierrez Borja⁹,Hamerly Timothy⁹,Sacarlal Jahit²,Aguilar Ruth¹,Dinglasan Rhoel R⁹,Moncunill Gemma¹³,Izquierdo Luis¹³,Dobaño Carlota¹³^ORCID

Affiliation:

1. Barcelona Institute for Global Health (ISGlobal), Hospital Clínic-Universitat de Barcelona , Barcelona, Catalonia , Spain

2. Centro de Investigação em Saúde de Manhiça , Maputo , Mozambique

3. Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC) , Barcelona , Spain

4. Université Claude Bernard Lyon 1, Université de Lyon , Villeurbanne , France

5. Institute of Biocomputation and Physics of Complex Systems, University of Zaragoza , Zaragoza , Spain

6. Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen , Copenhagen , Denmark

7. Fundación Agencia Aragonesa para la Investigación y el Desarrollo , Zaragoza , Spain

8. Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland , USA

9. Emerging Pathogens Institute, Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida , Gainesville, Florida , USA

Abstract

Abstract The RTS,S/AS02A malaria vaccine is based on the Plasmodium falciparum circumsporozoite protein (PfCSP), which is O-fucosylated on the sporozoite surface. We determined whether RTS,S/AS02A-induced immunoglobulin G (IgG) antibodies recognize vaccine-like nonfucosylated PfCSP better than native-like fucosylated PfCSP. Similar to previous vaccine trials, RTS,S/AS02A vaccination induced high anti-PfCSP IgG levels associated with malaria protection. IgG recognition of nonfucosylated and fucosylated PfCSP was equivalent, suggesting that PfCSP fucosylation does not affect antibody recognition. Clinical Trials Registration NCT00197041.

Funder

European

Social Fund

European Commission

Fondation Mérieux

Ministry of Science and Innovation, Spain

European Social Fund

PATH

GlaxoSmithKline Biologicals S.A

National Institutes of Health, National Institute of Allergy and Infectious Diseases

Spanish Agency for International Cooperation and Development

Spanish Ministry of Science and Innovation