Cumulative Detection of Anal High-Grade Squamous Intraepithelial Lesions Over 2-Year Follow-up in Men Who Have Sex With Men Living With Human Immunodeficiency Virus in France-Reference-Cited by-同舟云学术

Cumulative Detection of Anal High-Grade Squamous Intraepithelial Lesions Over 2-Year Follow-up in Men Who Have Sex With Men Living With Human Immunodeficiency Virus in France

Published:2023-11-16 Issue: Volume: Page:
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Combes Jean-Damien¹,Didelot Jean-Michel²,Radenne Sylvie³,Zaegel-Faucher Olivia⁴⁵,Lesage Anne-Carole⁶,Siproudhis Laurent⁷⁸⁹,Piroth Lionel¹⁰¹¹,Marchand Lucie¹²,Heard Isabelle¹³¹⁴,Hoyeau Nadia¹⁵,Henno Sébastien¹⁶,Darragh Teresa M¹⁷,Alberts Catharina J¹,Clifford Gary M¹^ORCID,Etienney Isabelle⁶,Arvieux Cédric,Canestri Ana,Clifford Gary,Combes Jean-Damien,Costes-Martineau Valérie,Del Grande Jean,Didelot Jean-Michel,Etienney Isabelle,Falguières Michael,Ferry Tristan,Fischer Hugues,Flejou Jean-Francois,Heard Isabelle,Henno Sébastien,Hoyau Nadia,Landon Marine,Laude Hélène,Le Breton Frédérique,Lesage Anne-Carole,Lion Annie,Maincent Gilles,Marchand Lucie,Andrianiaina Haingo Njatonirina,Patey Olivier,Sanchez Ventzislava Petrov,Pialoux Gilles,Pirel Marion,Piroth Lionel,Poizot-Martin Isabelle,Radenne Sylvie,Ressiot Emmanuelle,Reynes Jacques,Siproudhis Laurent,Tamalet Catherine,Tattevin Pierre,Zaegel-Faucher Olivia,

Affiliation:

1. International Agency for Research on Cancer (IARC/WHO), Early Detection, Prevention, and Infections Branch , Lyon , France

2. Service d'Hépatogastroentérologie, Centre Hospitalier Universitaire Montpellier , Montpellier , France

3. Service d'Hépatologie, Hôpital de la Croix Rousse , CHU Lyon, Lyon , France

4. Service d’Immuno-Hématologie Clinique, Université Aix Marseille, APHM Sainte-Marguerite , Marseille , France

5. INSERM U912 (Sciences Économiques et Sociales de la Santé et Traitement de l’Information Médicale—SESSTIM) , Université Aix Marseille, Marseille , France

6. Service de Proctologie Médico-Interventionnelle, Groupe Hospitalier Diaconesses Croix-Saint-Simon , Paris , France

7. Department of Gastroenterology, University Hospital of Rennes, Pontchaillou , Rennes , France

8. INSERM U1241, University of Rennes 1 , Rennes , France

9. INPHY CIC 1414 University Hospital of Rennes, Pontchaillou , Rennes , France

10. Département d’Infectiologie, Centre Hospitalier Universitaire (CHU) de Dijon , Dijon , France

11. Institut National de la Sante et de la Recherche Medicale (INSERM), Centre d’Investigation Clinique INSERM (CIC INSERM 1432), Université de Bourgogne , Dijon , France

12. Agence nationale de recherche sur le sida et les hépatites, Maladies infectieuses émergentes (ANRS-MIE) , Paris , France

13. Centre National de Référence des HPV, Institut Pasteur , Paris , France

14. Hôpital Tenon, AP-HP , Paris , France

15. Service d’Anatomie et Cytologie Pathologiques, Hôpital Saint-Antoine, Groupe Hospitalier Hôpitaux Universitaires Est Parisien (GH HUEP), AP-HP , Paris , France

16. Service d’Anatomie et Cytologie Pathologiques, CHU Pontchaillou , Rennes , France

17. Department of Pathology, University of California SanFrancisco , San Francisco, California , USA

Abstract

Abstract We assessed cumulative detection and determinants of anal high-grade squamous intraepithelial lesions (HSILs) in men who have sex with men living with human immunodeficiency virus and who underwent 3 visits over 2 years, with cytology and high-resolution anoscopy, within the ANRS-EP57-APACHES study. The cumulative HSIL detection rate was 33% (134 of 410), of which 48% HSILs were detected at baseline. HSIL detection varied considerably by center (from 13% to 51%). The strongest HSIL determinants were baseline human papillomavirus 16 (adjusted odds ratio, 8.2; 95% confidence interval, 3.6–18.9) and p16/Ki67 (4.6 [2.3–9.1]). Repeated annual cytology and high-resolution anoscopy improved HSIL detection but did not fully compensate for between-center heterogeneity.

Funder

ANRS

France Recherche Nord et Sud SIDA-HIV Hépatites

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiad506/54082243/jiad506.pdf

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