Neonatal BCG Vaccination Influences Cytokine Responses to Toll-like Receptor Ligands and Heterologous Antigens

Author:

Freyne Bridget12,Donath Susan32,Germano Susan1,Gardiner Kaya1,Casalaz Dan4,Robins-Browne Roy M15,Amenyogbe Nelly67,Messina Nicole L12,Netea Mihai G89,Flanagan Katie L1011,Kollmann Tobias67,Curtis Nigel1212

Affiliation:

1. Infectious Diseases and Microbiology Group, Parkville, Australia

2. Department of Paediatrics, Parkville, Australia

3. Clinical Epidemiology and Biostatistics Unit, Murdoch Children’s Research Institute, Parkville, Australia

4. Department of Paediatrics, Mercy Hospital for Women, Heidelberg, Australia

5. Department of Microbiology and Immunology, The University of Melbourne, Parkville, Australia

6. Department of Experimental Medicine, University of British Columbia, Vancouver, Canada

7. Division of Infectious Diseases, Department of Pediatrics, University of British Columbia, Vancouver, Canada

8. Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands

9. Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands

10. School of Medicine, University of Tasmania, Launceston Australia

11. Department of Immunology and Pathology, Monash University, Clayton, Australia

12. Infectious Diseases Unit, The Royal Children’s Hospital Melbourne, Parkville, Australia

Funder

Australian National Health and Medical Research Council (NHMRC)

European Research Council

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Reference50 articles.

1. Randomized trial of BCG vaccination at birth to low-birth-weight children: beneficial nonspecific effects in the neonatal period;Aaby;J Infect Dis,2011

2. The nonspecific effects of vaccines and the expanded program on immunization;Shann;J Infect Dis,2011

3. Non-specific effects of vaccines: plausible and potentially important, but implications uncertain;Pollard;Arch Dis Child,2017

4. Routine vaccinations and child survival: follow up study in Guinea-Bissau, West Africa;Kristensen;BMJ (Clinical research ed),2000

5. Association of BCG, DTP, and measles containing vaccines with childhood mortality: systematic review;Higgins;BMJ (Clinical research ed),2016

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