Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1-Reference-Cited by-同舟云学术

Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1

Published:2023-02-15 Issue:12 Volume:227 Page:1381-1385
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Poveda Eva¹^ORCID,Fitzgerald Wendy²,Reglero Cristina¹,Pérez-González Alexandre¹,Mariño Ana³,Álvarez Hortensia³,Valcarce Nieves³,Llibre Josep Maria⁴,Guillén Santiago Moreno⁵⁶⁷⁸,Muñoz Fernández Maria Angeles⁹,Ruiz-Mateos Ezequiel¹⁰,Margolis Leonid²,Lederman Michael M¹¹,Freeman Michael L¹¹

Affiliation:

1. Group of Virology and Pathogenesis, Galicia Sur Health Research Institute-Complexo Hospitalario Universitario de Vigo , Vigo , Spain

2. Section on Intercellular Interactions, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health , Bethesda, Maryland , USA

3. Infectious Diseases Unit, Complexo Hospitalario Universitario de Ferrol , A Coruña , Spain

4. Infectious Diseases Division, University Hospital Germans Trias and Fight Infections Foundation , Badalona , Spain

5. Department of Medicine, University of Alcalá , Alcalá de Henares , Spain

6. Ramón y Cajal Institute for Health Research , Madrid , Spain

7. Department of Infectious Diseases, Ramón y Cajal University Hospital , Madrid , Spain

8. Infectious Diseases Networking Biomedical Research Centre , Madrid , Spain

9. Hospital Gregorio Marañón BioBank , Madrid , Spain

10. Laboratory of Immunovirology, Clinical Unit of Infectious Diseases, Microbiology, and Parasitology, Institute of Biomedicine of Seville, Virgen del Rocío University Hospital, University of Seville , Seville , Spain

11. Rustbelt Center for AIDS Research, Division of Infectious Diseases and HIV Medicine, Case Western Reserve University , Cleveland, Ohio , USA

Abstract

Abstract Plasma extracellular vesicle (EV)-associated cytokines were quantified in people with HIV (PWH) with different virological control status, including elite controllers (EC) who maintain persistent control (PC) or not (TC). Cytokine signatures and pathways were determined for each group. Median EV-associated cytokine levels were higher among PWH than HIV-uninfected. EC showed the highest levels of EV-associated cytokines among PWH with PC levels higher than TC levels. IL-18 levels best distinguished PWH from uninfected controls, and EC from ART-treated, and IL-3 distinguished PC from TC. The role of EV-cytokines in intercellular communication and endogenous control of HIV expression should be investigated further.

Funder

Instituto de Salud Carlos III

European Regional Development Fund

Red Española de Investigación en SIDA

Fundación Biomédica Galicia Sur

HIV Biobank-Spanish HIV/AIDS Network

Case Western Reserve University Center for AIDS Research

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy