Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019-Reference-Cited by-同舟云学术

Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019

Published:2020-11-18 Issue:4 Volume:223 Page:562-567
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Bedin Anne-Sophie¹^ORCID,Makinson Alain²³,Picot Marie-Christine⁴⁵,Mennechet Frank¹,Malergue Fabrice⁶,Pisoni Amandine¹⁷,Nyiramigisha Esperance⁷,Montagnier Lise⁷,Bollore Karine¹,Debiesse Ségolène¹,Morquin David³,Bourgoin Pénélope⁶,Veyrenche Nicolas⁷,Renault Constance¹,Foulongne Vincent¹⁷,Bret Caroline⁸,Bourdin Arnaud⁹¹⁰,Le Moing Vincent²³,Van de Perre Philippe¹⁷,Tuaillon Edouard¹⁷

Affiliation:

1. Pathogenesis and Control of Chronic Infections, Montpellier University, INSERM, EFS, Montpellier, France

2. INSERM U1175/IRD UMI 233, IRD, Montpellier University, Montpellier, France

3. Department of Infectious Diseases, Montpellier University Hospital, Montpellier, France

4. INSERM, Centre d’Investigation Clinique 1411, Montpellier University, Montpellier, France

5. Montpellier University Hospital, Montpellier, France

6. Department of Research and Development, Immunotech-Beckman Coulter, Marseille, France

7. Laboratory of Virology, Montpellier University Hospital, France

8. Laboratory of Hematology, Montpellier University Hospital, France

9. Department of Respiratory Diseases, Montpellier University Hospital, Montpellier, France

10. PhyMedExp, Montpellier University, CNRS, INSERM, Montpellier, France

Abstract

Abstract We assessed the expression of CD169, a type I interferon-inducible receptor, on monocytes (monocyte CD169 [mCD169]) in 53 adult patients admitted to the hospital during the coronavirus disease 2019 (COVID-19) outbreak for a suspicion of severe acute respiratory syndrome coronavirus 2 infection. Monocyte CD169 was strongly overexpressed in 30 of 32 (93.7%) confirmed COVID-19 cases, compared with 3 of 21 (14.3%) patients in whom the diagnosis of COVID-19 was finally ruled out. Monocyte CD169 was associated with the plasma interferon-alpha level and thrombocytopenia. Monocyte CD169 testing may be helpful for the rapid triage of suspected COVID-19 patients during an outbreak.

Funder

University of Montpellier

Programme Hospitalier de Recherche Clinique Interrégional (PHRCI) Coro-TRI project

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiaa724/35726960/jiaa724.pdf

Reference15 articles.

1. Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients;Hadjadj;Science,2020

2. Increased expression of CD169 on blood monocytes and its regulation by virus and CD8 T cells in macaque models of HIV infection and AIDS;Kim;AIDS Res Hum Retroviruses,2015