Anti–Ebola Virus Antibody Levels in Convalescent Plasma and Viral Load After Plasma Infusion in Patients With Ebola Virus Disease-Reference-Cited by-同舟云学术

Anti–Ebola Virus Antibody Levels in Convalescent Plasma and Viral Load After Plasma Infusion in Patients With Ebola Virus Disease

Published:2018-04-11 Issue:4 Volume:218 Page:555-562
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Brown Jerry F¹,Dye John M²,Tozay Sam¹,Jeh-Mulbah Gertrude¹,Wohl David A³,Fischer William A³,Cunningham Coleen K⁴,Rowe Kathleen⁵,Zacharias Peter⁶,van Hasselt James⁶,Norwood David A²,Thielman Nathan M⁴,Zak Samantha E²,Hoover David L⁷

Affiliation:

1. Eternal Love Winning Africa Hospital, Paynesville, Liberia

2. US Army Medical Research Institute of Infectious Disease, Frederick, Maryland

3. University of North Carolina School of Medicine, Chapel Hill

4. Duke University School of Medicine, Durham, North Carolina

5. Blood Centers of America, West Warwick, Rhode Island

6. Safe Blood for Africa Foundation, Washington, District of Columbia, Hinckley, Ohio

7. Clinical Research Management, Inc, Hinckley, Ohio

Abstract

Enzyme-linked immunosorbent and microneutralization assays of 180 Ebola convalescent plasma specimens were highly concordant and predictive for detection of antibody by 50% plaque reduction neutralization test. Viral load decreased following infusion of antibody-containing plasma in 2 Ebola virus disease patients.

Funder

NIH

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/article-pdf/218/4/555/31191318/jiy199.pdf

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