Subclinical Atherosclerosis Across the Menopausal Transition in Women With and Without HIV

Author:

Peters Brandilyn A1ORCID,Whalen Adam1,Xue Xiaonan1,Topper Elizabeth F2,Weber Kathleen M3,Tien Phyllis C45,Kassaye Seble G6,Minkoff Howard7,Fox Ervin8,Fischl Margaret A9,Collins Lauren F10ORCID,Floris-Moore Michelle11,Hodis Howard N12,Qi Qibin1,Hanna David B1,Sharma Anjali13,Anastos Kathryn13,Kaplan Robert C114

Affiliation:

1. Department of Epidemiology and Population Health, Albert Einstein College of Medicine , Bronx, New York , USA

2. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland , USA

3. Cook County Health and Hospital System/Hektoen Institute of Medicine CORE Center of , Chicago, Illinois , USA

4. Division of Infectious Diseases, University of California San Francisco , San Francisco, California , USA

5. Medical Service, Department of Veterans Affairs , San Francisco, California , USA

6. Department of Medicine, Georgetown University Medical Center , Washington, District of Columbia , USA

7. Department of Obstetrics and Gynecology, State University of New York Downstate Health Sciences University , Brooklyn, New York , USA

8. Department of Medicine, University of Mississippi Medical Center , Jackson, Mississippi , USA

9. Division of Infectious Diseases, University of Miami Miller School of Medicine , Miami, Florida , USA

10. Division of Infectious Diseases, Emory University School of Medicine , Atlanta, Georgia , USA

11. Department of Medicine, University of North Carolina School of Medicine , Chapel Hill, North Carolina , USA

12. Departments of Medicine and Population and Public Health Sciences, Atherosclerosis Research Unit, Keck School of Medicine, University of Southern California , Los Angeles, California , USA

13. Department of Medicine, Albert Einstein College of Medicine , Bronx, New York , USA

14. Public Health Sciences Division, Fred Hutchinson Cancer Research Center , Seattle, Washington , USA

Abstract

Abstract The menopausal transition is a pivotal time of cardiovascular risk, but knowledge is limited in HIV. We studied longitudinal carotid artery intima-media thickness (CIMT) in the Women's Interagency HIV Study (2004–2019; 979 women/3247 person-visits; 72% with HIV). Among women with HIV only, those who transitioned had greater age-related CIMT progression compared to those remaining premenopausal (difference in slope = 1.64 µm/year, P = .002); and CIMT increased over time in the pretransition (3.47 µm/year, P = .002) and during the menopausal transition (9.41 µm/year, P < .0001), but not posttransition (2.9 µm/year, P = .19). In women with HIV, menopause may accelerate subclinical atherosclerosis as measured by CIMT.

Funder

National Heart, Lung, and Blood Institute

Eunice Kennedy Shriver National Institute of Child Health and Human Development

National Institute On Aging

National Institute Of Dental and Craniofacial Research

National Institute Of Allergy And Infectious Diseases

National Institute Of Neurological Disorders And Stroke

National Institute Of Mental Health

National Institute On Drug Abuse

National Institute Of Nursing Research

National Cancer Institute

National Institute on Alcohol Abuse and Alcoholism

National Institute on Deafness and Other Communication Disorders

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute on Minority Health and Health Disparities

NIH

Office of AIDS Research

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

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