Genome-Wide Sequence Analysis of Kaposi Sarcoma-Associated Herpesvirus Shows Diversification Driven by Recombination-Reference-Cited by-同舟云学术

Genome-Wide Sequence Analysis of Kaposi Sarcoma-Associated Herpesvirus Shows Diversification Driven by Recombination

Published:2018-07-14 Issue:11 Volume:218 Page:1700-1710
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Sallah Neneh¹^ORCID,Palser Anne L²,Watson Simon J²,Labo Nazzarena³,Asiki Gershim⁴,Marshall Vickie³,Newton Robert⁴,Whitby Denise³,Kellam Paul²⁵,Barroso Inês¹^ORCID

Affiliation:

1. Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge

2. Kymab Ltd, Babraham Research Complex, Cambridge

3. AIDS and Cancer Virus Program, Viral Oncology Section, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Maryland

4. Medical Research Council/Uganda Virus Research Institute, Uganda Research Unit, London School of Hygiene and Tropical Medicine, United Kingdom

5. Department of Medicine, Imperial College London, United Kingdom

Abstract

This study presents 45 new KSHV genomes sequenced from Uganda, a KSHV endemic region. We present new evidence for the presence of inter- and intragenic recombination across genomes contributing to the diversification of KSHV strains into at least 5 types.

Funder

Medical Research Council

Department for International Development

Wellcome Trust

National Cancer Institute

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/article-pdf/218/11/1700/26120318/jiy427.pdf