Development and Pilot of an Mpox Severity Scoring System (MPOX-SSS)

Author:

Zucker Jason1ORCID,McLean Jacob1,Huang Simian1,DeLaurentis Clare1,Gunaratne Shauna1,Stoeckle Kate2,Glesby Marshall J2,Wilkin Timothy J2,Fischer William3ORCID,Brooks John T4,Damon Inger4

Affiliation:

1. Division of Infectious Diseases, Columbia University Vagelos College of Physicians and Surgeons

2. Division of Infectious Diseases , Weill Cornell Medicine

3. Institute of Global Health and Infectious Diseases, The University of North Carolina (UNC) at Chapel Hill

4. Centers for Disease Control and Prevention

Abstract

Abstract Clinical severity scores facilitate comparisons to understand risk factors for severe illness. For the 2022 multinational monkeypox Clade IIb virus outbreak, we developed a 7-item mpox severity scoring system (MPOX-SSS) with initial variables refined based on data availability and parameter correlation. Application of MPOX-SSS to the first 200 patients diagnosed with mpox revealed higher scores in those treated with tecovirimat, presenting >3 days after symptom onset and with CD4 counts <200 cells/mm3 . For individuals evaluated repeatedly, serial scores were concordant with clinical observations. The pilot MPOX-SSS demonstrated good discrimination, distinguished change over time, and identified higher scores in expected groups.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

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