Transmission Potential of Asymptomatic and Paucisymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infections: A 3-Family Cluster Study in China-Reference-Cited by-同舟云学术

Transmission Potential of Asymptomatic and Paucisymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infections: A 3-Family Cluster Study in China

Published:2020-04-22 Issue:12 Volume:221 Page:1948-1952
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Jiang Xiao-Lin¹,Zhang Xiao-Li²,Zhao Xiang-Na³,Li Cun-Bao⁴,Lei Jie¹,Kou Zeng-Qiang¹,Sun Wen-Kui¹,Hang Yang¹,Gao Feng⁵,Ji Sheng-Xiang²,Lin Can-Fang⁴,Pang Bo¹,Yao Ming-Xiao¹,Anderson Benjamin D⁶,Wang Guo-Lin⁷,Yao Lin⁷,Duan Li-Jun⁷,Kang Dian-Min¹,Ma Mai-Juan⁷^ORCID

Affiliation:

1. Shandong Provincial Center for Disease Control and Prevention, Jinan, China

2. Linyi Center for Disease Control and Prevention, Linyi, China

3. Institute of Disease Control and Prevention, Chinese People’s Liberation Army, Beijing, China

4. Lanshan District Center for Disease Control and Prevention, Linyi, China

5. Linyi People’s Hospital, Linyi, China

6. Global Health Research Center, Duke Kunshan University, Kunshan, Jiangsu, China

7. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China

Abstract

Abstract Data concerning the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in asymptomatic and paucisymptomatic patients are lacking. We report a 3-family cluster of infections involving asymptomatic and paucisymptomatic transmission. Eight of 15 (53%) members from 3 families were confirmed with SARS-CoV-2 infection. Of 8 patients, 3 were asymptomatic and 1 was paucisymptomatic. An asymptomatic mother transmitted the virus to her son, and a paucisymptomatic father transmitted the virus to his 3-month-old daughter. SARS-CoV-2 was detected in the environment of 1 household. The complete genomes of SARS-CoV-2 from the patients were > 99.9% identical and were clustered with other SARS-CoV-2 sequences reported from China and other countries.

Funder

Special National Project on Investigation of Basic Resources of China

National Major Project for Control and Prevention of Infectious Disease of China

Key Technology Research and Development Program of Shandong

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiaa206/33146776/jiaa206.pdf

Reference15 articles.

1. A novel coronavirus from patients with pneumonia in China, 2019;Zhu;N Engl J Med,2020

2. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster;Chan;Lancet,2020

3. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China [in Chinese];Novel Coronavirus Pneumonia Emergency Response Epidemiology Team;Zhonghua Liu Xing Bing Xue Za Zhi,2020

4. Transmission of 2019-nCoV infection from an asymptomatic contact in Germany;Rothe;N Engl J Med,2020

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