New Insights Into the Kinetics and Variability of Egg Excretion in Controlled Human Hookworm Infections-Reference-Cited by-同舟云学术

New Insights Into the Kinetics and Variability of Egg Excretion in Controlled Human Hookworm Infections

Published:2019-05-11 Issue:6 Volume:220 Page:1044-1048
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Hoogerwerf Marie-Astrid¹^ORCID,Coffeng Luc E²,Brienen Eric A T¹,Janse Jacqueline J¹^ORCID,Langenberg Marijke C C¹,Kruize Yvonne C M¹,Gootjes Chelsea¹,Manurung Mikhael D¹,Dekker Mark¹,Becker Luke³,Erkens Marianne A A⁴,van der Beek Martha T⁴,Ganesh Munisha S¹,Feijt Carola¹,Winkel Beatrice M F¹,Westra Inge M⁵,Meij Pauline⁵,Loukas Alex³,Visser Leo G⁶,de Vlas Sake J²,Yazdanbakhsh Maria¹,van Lieshout Lisette¹,Roestenberg Meta¹⁶

Affiliation:

1. Department of Parasitology, Leiden University Medical Center, Leiden

2. Department of Public Health, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, the Netherlands

3. Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns

4. Clinical Microbiology Laboratory, Leiden University Medical Center, Leiden

5. Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden

6. Department of Infectious Diseases, Leiden University Medical Center, Leiden

Abstract

Abstract Four healthy volunteers were infected with 50 Necator americanus infective larvae (L3) in a controlled human hookworm infection trial and followed for 52 weeks. The kinetics of fecal egg counts in volunteers was assessed with Bayesian multilevel analysis, which revealed an increase between weeks 7 and 13, followed by an egg density plateau of about 1000 eggs/g of feces. Variation in egg counts was minimal between same-day measurements but varied considerably between days, particularly during the plateau phase. These analyses pave the way for the controlled human hookworm model to accelerate drug and vaccine efficacy studies.

Funder

Dutch Society for Scientific Research

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiz218/28792077/jiz218.pdf

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